TYROBP and NCR2

Number of citations of the paper that reports this interaction (PubMedID 10049942)
27

Data Source:
HPRD (in vivo)

		TYROBP	NCR2
Description		transmembrane immune signaling adaptor TYROBP	natural cytotoxicity triggering receptor 2
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane	Plasma Membrane Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Cytokine Production Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Immune Effector Process Myeloid Leukocyte Activation Macrophage Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Immune System Process Positive Regulation Of Immune System Process Defense Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Response To Axon Injury Protein Stabilization Regulation Of Biological Quality Semaphorin-plexin Signaling Pathway Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cellular Response To Amyloid-beta Positive Regulation Of Protein Localization To Cell Surface Regulation Of Osteoclast Development Positive Regulation Of Osteoclast Development	Cellular Defense Response Signal Transduction
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions
Drugs
Diseases		Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS			Alzheimer's disease biomarkers ( 23562540) Periodontitis ( 23459936) Telomere length ( 29151059) Total ventricular volume ( 21116278)
Interacting Genes		15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70	1 interacting genes: TYROBP
Entrez ID		7305	9436
HPRD ID		04996	05168
Ensembl ID		ENSG00000011600	ENSG00000096264
Uniprot IDs		O43914 X6RGC9	O95944
PDB IDs		2L34 2L35 4WO1 4WOL 7Q5W	1HKF
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Transmembrane Signaling Receptor Activity Regulation Of Immune Response Immune System Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Membrane Regulation Of Innate Immune Response Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Beta Selection Positive Regulation Of Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Cellular Defense Response Regulation Of Cell Activation Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune Response Carbohydrate Binding Innate Immune Response-activating Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Calcium-mediated Signaling Regulation Of Natural Killer Cell Mediated Immunity Plasma Membrane Activation Of Immune Response Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Activation Of Innate Immune Response Positive Regulation Of Cell Killing Immune Response Scaffold Protein Binding Positive Regulation Of Defense Response Lymphocyte Activation Regulation Of Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Defense Response Regulation Of Calcium-mediated Signaling Signaling Receptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Leukocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phagocytosis Adaptive Immune Response	Positive Regulation Of Osteoclast Development Microglial Cell Activation Involved In Immune Response Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Transforming Growth Factor Beta1 Production T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Osteoclast Development Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of B Cell Proliferation Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Interleukin-10 Production Macrophage Activation Involved In Immune Response Regulation Of Superoxide Anion Generation Microglial Cell Activation Cellular Response To Lectin Regulation Of Receptor Localization To Synapse Positive Regulation Of Superoxide Anion Generation Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Activation Regulation Of Superoxide Metabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Amyloid-beta Clearance Apoptotic Cell Clearance Neutrophil Activation Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of B Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Protein Localization To Cell Surface Regulation Of Long-term Synaptic Potentiation Regulation Of Natural Killer Cell Activation Semaphorin-plexin Signaling Pathway Natural Killer Cell Mediated Immunity Negative Regulation Of Type I Interferon Production Osteoclast Differentiation Cellular Response To Amyloid-beta Cellular Defense Response Response To Axon Injury Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of B Cell Proliferation Macrophage Activation Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Response To Amyloid-beta Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity T Cell Activation Involved In Immune Response
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