KLRK1 and ULBP3

Number of citations of the paper that reports this interaction (PubMedID 11754823)
0

Data Source:
HPRD (in vitro)

		KLRK1	ULBP3
Description		killer cell lectin like receptor K1	UL16 binding protein 3
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Protein Binding Carbohydrate Binding MHC Class Ib Receptor Activity Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding	Protein Binding Natural Killer Cell Lectin-like Receptor Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Immune System Process Nitric Oxide Biosynthetic Process Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Positive Regulation Of Type II Interferon Production Negative Regulation Of GTPase Activity Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Defense Response To Gram-positive Bacterium Positive Regulation Of Multicellular Organismal Process Cellular Response To Lipopolysaccharide Defense Response To Other Organism Negative Regulation Of Natural Killer Cell Chemotaxis	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Interleukin-1-receptor antagonist levels ( 22205395) Obesity-related traits ( 23251661) Psoriasis ( 28537254)	Alopecia areata ( 20596022 25608926) Cerebral amyloid angiopathy in APOEe4 non-carrier Alzheimer’s disease ( 34020725) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Metabolite levels (HVA/5-HIAA ratio) ( 23319000)
Interacting Genes		8 interacting genes: HCST MICB PDE4C RAE1 RAET1E RAET1G TYROBP ULBP3	1 interacting genes: KLRK1
Entrez ID		22914	79465
HPRD ID		17240	16144
Ensembl ID		ENSG00000213809	ENSG00000131019
Uniprot IDs		P26718	Q9BZM4
PDB IDs		1HYR 1KCG 1MPU 4PDC 4S0U 8TM0 8TM2 9DH2	1KCG
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Lectin-like Receptor Binding Natural Killer Cell Mediated Immunity Lymphocyte Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Cell Killing Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Immune Effector Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response Regulation Of T Cell Mediated Cytotoxicity Immune Response Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Immune Effector Process Innate Immune Response Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Immune Response Defense Response To Symbiont Defense Response To Other Organism Antigen Processing And Presentation External Side Of Plasma Membrane Regulation Of T Cell Mediated Immunity Regulation Of Immune System Process Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Immune System Process Immune System Process Response To Other Organism Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Response To External Biotic Stimulus Positive Regulation Of Natural Killer Cell Mediated Immunity Defense Response Extracellular Space Positive Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Natural Killer Cell Mediated Immunity Response To Stress Regulation Of Innate Immune Response Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway	Negative Regulation Of Lymphocyte Chemotaxis Negative Regulation Of Natural Killer Cell Chemotaxis MHC Class Ib Receptor Activity Negative Regulation Of Lymphocyte Migration MHC Class I Protein Binding Negative Regulation Of Leukocyte Chemotaxis Cellular Response To Lectin Negative Regulation Of GTPase Activity Stimulatory C-type Lectin Receptor Signaling Pathway Nitric Oxide Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Nitric Oxide Metabolic Process Negative Regulation Of Hydrolase Activity Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity T Cell Costimulation Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Reactive Nitrogen Species Metabolic Process Regulation Of Lymphocyte Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Chemotaxis Negative Regulation Of Leukocyte Migration Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Migration Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Leukocyte Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Defense Response To Gram-positive Bacterium Regulation Of Type II Interferon Production Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Regulation Of GTPase Activity Regulation Of Mononuclear Cell Migration Leukocyte Mediated Immunity Negative Regulation Of Catalytic Activity Carbohydrate Binding Innate Immune Response-activating Signaling Pathway Cell Killing Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Regulation Of Lymphocyte Mediated Immunity
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