TYROBP and TREM1

Number of citations of the paper that reports this interaction (PMID 10799849)
126

Data Source:
HPRD (in vivo)

		TYROBP	TREM1
Gene Name		TYRO protein tyrosine kinase binding protein	triggering receptor expressed on myeloid cells 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Signaling Protein Activity Receptor Binding Protein Binding Identical Protein Binding	Receptor Activity Scaffold Protein Binding
	Biological Process	Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Integrin-mediated Signaling Pathway Axon Guidance Intracellular Signal Transduction Innate Immune Response Regulation Of Immune Response Regulation Of Osteoclast Development	Cytokine Secretion Involved In Immune Response Humoral Immune Response Blood Coagulation Neutrophil Chemotaxis Intracellular Signal Transduction Innate Immune Response Chemokine Metabolic Process Leukocyte Migration Neutrophil Mediated Killing Of Gram-negative Bacterium Neutrophil Extravasation
Pathways		DAP12 signaling DAP12 interactions Axon guidance Semaphorin interactions Other semaphorin interactions Signal regulatory protein (SIRP) family interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	DAP12 interactions Cell surface interactions at the vascular wall Innate Immune System
Drugs			D-tartaric acid
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SYK TREM1 TREM2 ZAP70	1 interactors: TYROBP
Entrez ID		7305	54210
HPRD ID		04996	05472
Ensembl ID		ENSG00000011600	ENSG00000124731
Uniprot IDs		O43914	K7EJW1 Q38L15 Q9NP99
PDB IDs		2L34 2L35	1Q8M 1SMO
Enriched GO Terms of Interacting Partners?		Defense Response Innate Immune Response Immune Response Response To Stress Immune System Process Cellular Defense Response Beta Selection Positive Regulation Of Calcium-mediated Signaling Response To Stimulus Regulation Of Calcium-mediated Signaling Positive Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Activation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Leukocyte Migration T Cell Selection Positive Regulation Of Alpha-beta T Cell Differentiation Hemopoiesis Positive Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Signal Transduction Locomotion Neutrophil Chemotaxis Neutrophil Migration Cell Activation Immune System Development Response To Other Organism Granulocyte Chemotaxis Regulation Of T Cell Activation Positive Regulation Of Cell Activation Natural Killer Cell Activation Alpha-beta T Cell Differentiation Response To Biotic Stimulus Positive Regulation Of CD40 Signaling Pathway Cytokine Secretion Involved In Immune Response Detection Of Lipoteichoic Acid Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Signaling Alpha-beta T Cell Activation Leukocyte Differentiation Cell Communication Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation	Regulation Of Osteoclast Development Neutrophil Activation Involved In Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Macrophage Activation Cellular Defense Response Regulation Of Osteoclast Differentiation Regulation Of Myeloid Leukocyte Differentiation Integrin-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation
Tagcloud ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate trem2 triggering	1x10 3x10 6x10 7x10 9x10 aging cohorts copyright cytometric decline endophenotypes gwas intronic neuritic neurofibrillary neuropathological plaques pursue reserved rights rs6910730g rs7759295c tangle tangles trem2 treml2 triggering variants
Tagcloud (Difference) ?		acts ad adaptor articles beta1 complement concerning convincing cr3 dendritic elusive emerging introduce meanwhile microglia opportunities osteoclasts participate participates pathogenesis phagocytic piece playing repression sirpbeta1 speculate	1x10 3x10 6x10 7x10 9x10 aging cohorts copyright cytometric decline endophenotypes gwas intronic neuritic neurofibrillary neuropathological plaques pursue reserved rights rs6910730g rs7759295c tangle tangles treml2 variants
Tagcloud (Intersection) ?		trem2 triggering