IKZF4 and FOXP3

Number of citations of the paper that reports this interaction (PMID 19696312)
46

Data Source:
BioGRID (pull down, two hybrid)

		IKZF4	FOXP3
Gene Name		IKAROS family zinc finger 4 (Eos)	forkhead box P3
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Protein Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter B Cell Homeostasis Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Mediated Immunity Tolerance Induction To Self Antigen Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction Chromatin Remodeling Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Histone Acetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Cytokine Biosynthetic Process T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cytokine Secretion Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Alopecia areata ( 20596022) Asthma ( 21804548) Type 1 diabetes ( 18198356) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22561518)
Protein-Protein Interactions		12 interactors: CHD4 FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 NFKBIA NRG1 SIN3A SIN3B	9 interactors: EP300 IKZF4 KAT8 NFAT5 NFATC2 PRR20A RBPMS RUNX1 STUB1
Entrez ID		64375	50943
HPRD ID		05874	02242
Ensembl ID		ENSG00000123411	ENSG00000049768
Uniprot IDs		G5E9S4 Q9H2S9	Q9BZS1
PDB IDs		2MA7	3QRF
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Chromatin Modification Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cardiac Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone Deacetylation Nucleobase-containing Compound Metabolic Process Protein Deacetylation Positive Regulation Of Cellular Biosynthetic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Striated Muscle Tissue Development Muscle Tissue Development Regulation Of Immune System Process Cardiac Muscle Cell Differentiation Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cardiocyte Differentiation Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Histone Acetylation Negative Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H2B Acetylation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Negative Regulation Of Gene Expression ER-nucleus Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Response To Topologically Incorrect Protein Histone Acetylation Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Progesterone Secretion Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Response To Unfolded Protein Protein Acetylation Regulation Of Signal Transduction Cytokine Production N-terminal Peptidyl-lysine Acetylation Regulation Of Progesterone Secretion
Tagcloud ?			17a administrated asthmatic balf bas basophils bsyqf dex eos ethnopharmacological formulae hematoxylin hyperresponsiveness imbalance lym mch methacholine mon ova ovalbumin plex prominently qi rorgammat schiff shen th17 treg yi
Tagcloud (Difference) ?			17a administrated asthmatic balf bas basophils bsyqf dex eos ethnopharmacological formulae hematoxylin hyperresponsiveness imbalance lym mch methacholine mon ova ovalbumin plex prominently qi rorgammat schiff shen th17 treg yi
Tagcloud (Intersection) ?