IKZF4 and TCAF1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		IKZF4	TCAF1
Name		IKAROS family zinc finger 4	TRPM8 channel associated factor 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Protein-containing Complex	Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Transmembrane Transporter Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization	Negative Regulation Of Cell Migration Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Anion Channel Activity
GWAS		Age at first birth ( 34211149 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Alopecia areata ( 20596022 25608926 ) Anorexia nervosa ( 28494655 ) Asthma ( 32700739 31959851 31619474 21804548 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Autoimmune traits (pleiotropy) ( 30572963 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive function ( 25644384 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Neutrophil percentage of granulocytes ( 27863252 ) Refractive error ( 32231278 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Type 1 diabetes ( 21829393 25751624 18198356 ) Vitiligo ( 27723757 22561518 )	No GWAS studies recorded
Interacting Genes		20 interacting genes: CDC7 CHD4 CSNK1D FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 MCRS1 MOB1A MOB3C NFKBIA NRG1 SIN3A SIN3B TCAF1 TCEA2 TXK	36 interacting genes: BIRC2 CAMK2A CEP70 CNKSR1 COIL CYSRT1 DISC1 EFEMP2 IKZF3 IKZF4 KRTAP1-3 KRTAP10-8 KRTAP13-2 KRTAP6-3 MAD1L1 MID2 NBPF19 NFYA PRDM14 PRDM6 RBAK SCYL3 SF3B4 SPRY2 TAX1BP1 TCF3 TFIP11 TRAF2 TRIM42 TRIM54 TRIP6 UBC ZNF143 ZNF24 ZNF263 ZNF592
Entrez ID		64375	9747
HPRD ID		05874	13813
Ensembl ID		ENSG00000123411	ENSG00000198420
Uniprot IDs		F8VPL6 Q9H2S9	B4DST7 Q9Y4C2
PDB IDs		2MA7	Not available
GO Terms Enriched among Interactors		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Sin3-type Complex Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II NF-kappaB Binding Histone Deacetylase Binding Cellular Response To Dopamine Negative Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Zinc Ion Binding NuRD Complex DNA Recombination Protein-containing Complex Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Catecholamine Stimulus Positive Regulation Of Macromolecule Metabolic Process Response To Catecholamine Chromatin Organization Regulation Of Cell Fate Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle G2/M Phase Transition Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Locomotion	Zinc Ion Binding Identical Protein Binding