IKZF4 and IKZF5

Number of citations of the paper that reports this interaction (PMID 10978333)
15

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		IKZF4	IKZF5
Gene Name		IKAROS family zinc finger 4 (Eos)	IKAROS family zinc finger 5 (Pegasus)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity	DNA Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Alopecia areata ( 20596022) Asthma ( 21804548) Type 1 diabetes ( 18198356) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22561518)
Protein-Protein Interactions		12 interactors: CHD4 FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 NFKBIA NRG1 SIN3A SIN3B	6 interactors: CCDC85B IKZF1 IKZF2 IKZF3 IKZF4 LDOC1
Entrez ID		64375	64376
HPRD ID		05874	05873
Ensembl ID		ENSG00000123411	ENSG00000095574
Uniprot IDs		G5E9S4 Q9H2S9	Q9H5V7
PDB IDs		2MA7
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Chromatin Modification Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cardiac Muscle Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone Deacetylation Nucleobase-containing Compound Metabolic Process Protein Deacetylation Positive Regulation Of Cellular Biosynthetic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Striated Muscle Tissue Development Muscle Tissue Development Regulation Of Immune System Process Cardiac Muscle Cell Differentiation Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cardiocyte Differentiation Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Histone Acetylation Negative Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Neutrophil Differentiation Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Mesoderm Development Regulation Of Lymphocyte Differentiation B Cell Activation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of NK T Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Granulocyte Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Lymphocyte Activation Lymph Node Development Lymphocyte Activation Positive Regulation Of Macromolecule Biosynthetic Process Peyer's Patch Development Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Natural Killer Cell Differentiation Regulation Of Cell Activation Leukocyte Activation Regulation Of B Cell Differentiation Regulation Of Growth Negative Regulation Of Cellular Metabolic Process Cell Activation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Multicellular Organism Growth
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