IKZF4 and CHD4

Number of citations of the paper that reports this interaction (PubMedID 12015313)
0

Data Source:
HPRD (in vivo)

		IKZF4	CHD4
Description		IKAROS family zinc finger 4	chromodomain helicase DNA binding protein 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Protein-containing Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Membrane NuRD Complex Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage Cerebellar Granule Cell To Purkinje Cell Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding	Nucleotide Binding Transcription Coregulator Binding DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Chromatin Remodeling Negative Regulation Of Gene Expression Oxygen Transport Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Synapse Assembly Terminal Button Organization Regulation Of Stem Cell Differentiation
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Alopecia areata ( 20596022 25608926) Anorexia nervosa ( 28494655) Asthma ( 32700739 31959851 31619474 21804548) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune traits (pleiotropy) ( 30572963) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cognitive function ( 25644384) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil percentage of granulocytes ( 27863252) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Type 1 diabetes ( 21829393 25751624 18198356) Vitiligo ( 27723757 22561518)	Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Myopia (pathological) ( 23049088)
Interacting Genes		20 interacting genes: CDC7 CHD4 CSNK1D FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 MCRS1 MOB1A MOB3C NFKBIA NRG1 SIN3A SIN3B TCAF1 TCEA2 TXK	27 interacting genes: ATM ATR CDR1 CEBPA EP300 EPAS1 H2AC4 H2BC3 H3-4 H3C1 H4C1 HDAC1 HIF1A IKZF4 MTNR1A NCAM2 PSTPIP1 PTEN RNF8 RORC SMARCA4 SUMO2 TRIM27 TTN TWIST1 UBE2I XRN1
Entrez ID		64375	1108
HPRD ID		05874	04472
Ensembl ID		ENSG00000123411	ENSG00000111642
Uniprot IDs		F8VPL6 Q9H2S9	A0A2U3TZM0 F5GWX5 Q14839
PDB IDs		2MA7	1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG 6Q3M 6RYR 6RYU 8D4Y
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Sin3-type Complex Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II NF-kappaB Binding Histone Deacetylase Binding Cellular Response To Dopamine Negative Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Zinc Ion Binding NuRD Complex DNA Recombination Protein-containing Complex Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Catecholamine Stimulus Positive Regulation Of Macromolecule Metabolic Process Response To Catecholamine Chromatin Organization Regulation Of Cell Fate Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle G2/M Phase Transition Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Locomotion	Chromatin Remodeling DNA Binding Chromatin Organization Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Heterodimerization Activity Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Structural Constituent Of Chromatin Negative Regulation Of Macromolecule Metabolic Process Chromosome, Telomeric Region Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coregulator Binding Negative Regulation Of Metabolic Process Chromosome PML Body Nucleus Nucleosome Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Circadian Rhythm Nucleosome Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Double-strand Break Repair SUMO Transferase Activity Positive Regulation Of Macromolecule Metabolic Process P53 Binding Negative Regulation Of RNA Metabolic Process Histone H2AXS139 Kinase Activity Negative Regulation Of T Cell Apoptotic Process Epithelial Cell Maturation Regulation Of Transcription By RNA Polymerase II Embryonic Placenta Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression
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