CDK11A and GADD45A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CDK11A	GADD45A
Description		cyclin dependent kinase 11A	growth arrest and DNA damage inducible alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of Centrosome Cycle Regulation Of MRNA Processing Regulation Of Cell Cycle	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Apoptotic Process DNA Damage Response Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Recruitment of mitotic centrosome proteins and complexes	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		7 interacting genes: B4GALT1 CCNL1 GADD45A GADD45G PIN1 SKIC2 SPDEF	69 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B CNOT9 DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4C16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PARVG PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135
Entrez ID		728642	1647
HPRD ID			00528
Ensembl ID		ENSG00000008128	ENSG00000116717
Uniprot IDs		Q4VBY6 Q5QPR3 Q9UQ88	A5JUZ3 P24522
PDB IDs			2KG4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of P38MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of P38MAPK Cascade Regulation Of Cell Cycle Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Circulating Fibrinogen Levels Cis-trans Isomerase Activity Nuclear Speck Positive Regulation Of JNK Cascade Epithelial Cell Development Lactose Biosynthetic Process UDP-galactosyltransferase Activity Lactose Synthase Activity Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Lung Goblet Cell Differentiation Regulation Of JNK Cascade N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Regulation Of MAPK Cascade Glandular Epithelial Cell Development Development Of Secondary Sexual Characteristics Phosphoserine Residue Binding Negative Regulation Of Peptidyl-serine Phosphorylation Galactosyltransferase Activity 3'-5' RNA Helicase Activity Golgi Trans Cisterna Disaccharide Metabolic Process Galactose Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Penetration Of Zona Pellucida Mitogen-activated Protein Kinase Kinase Binding Intestinal Epithelial Cell Development GTPase Activating Protein Binding Ubiquitin Ligase Activator Activity Epithelial Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Regulation Of Acrosome Reaction Negative Regulation Of Cell Fate Commitment	Cellular Response To UV Response To UV Cellular Response To Light Stimulus Protein Kinase Binding Stress-induced Premature Senescence Molecular Function Activator Activity Nucleoplasm Positive Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Radiation Regulation Of Heart Growth Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Glucose Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Heart Growth Cyclin B1-CDK1 Complex PCNA-p21 Complex Nucleus Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Chromatin Organization Structural Constituent Of Chromatin Response To UV-C Regulation Of Growth Negative Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Extracellular Exosome Identical Protein Binding Cytosol Positive Regulation Of Organ Growth Regulation Of Developmental Growth Regulation Of Organ Growth Protein Localization To Organelle Centrosome Cycle Response To Light Stimulus Cellular Response To Actinomycin D Negative Regulation Of Biosynthetic Process Hexose Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Cellular Response To Nutrient Levels Protein Binding Nucleosome Assembly Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Actinomycin D
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