CDK11A and CCNL1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		CDK11A	CCNL1
Description		cyclin dependent kinase 11A	cyclin L1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of Centrosome Cycle Regulation Of MRNA Processing Regulation Of Cell Cycle	Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of Centrosome Cycle Regulation Of Cell Cycle
Pathways		Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Adiponectin levels in pregnancy ( 28317342) Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Anthropometric traits in newborns ( 23575227) Birth weight ( 20372150 23202124 31453325 31043758 27680694) Birth weight variance ( 31453325) Body fat percentage variance ( 31453325) Body mass index ( 26426971) circulating leptin levels ( 32917775 26833098) circulating leptin levels adjusted for BMI ( 26833098 32917775) Coronary artery disease ( 33020668) Diabetic retinopathy ( 21441570) Eating disorders ( 22911880) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Menarche (age at onset) ( 25231870) Offspring birth weight ( 31043758) PR interval ( 32439900 30046033) Smoking cessation in chronic obstructive pulmonary disease ( 21685187)
Interacting Genes		7 interacting genes: B4GALT1 CCNL1 GADD45A GADD45G PIN1 SKIC2 SPDEF	21 interacting genes: APP APPBP2 C1orf35 CASP8 CDK11A DVL3 FAM133A JMJD6 KRTAP12-2 NKAPD1 PRDM6 PRPF40A RAD51D RNPS1 RSRP1 SORBS3 SREK1IP1 SRSF2 TFIP11 ZRANB1 ZRSR2
Entrez ID		728642	57018
HPRD ID			10814
Ensembl ID		ENSG00000008128	ENSG00000163660
Uniprot IDs		Q4VBY6 Q5QPR3 Q9UQ88	Q9UK58
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of P38MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of P38MAPK Cascade Regulation Of Cell Cycle Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Circulating Fibrinogen Levels Cis-trans Isomerase Activity Nuclear Speck Positive Regulation Of JNK Cascade Epithelial Cell Development Lactose Biosynthetic Process UDP-galactosyltransferase Activity Lactose Synthase Activity Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Lung Goblet Cell Differentiation Regulation Of JNK Cascade N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Regulation Of MAPK Cascade Glandular Epithelial Cell Development Development Of Secondary Sexual Characteristics Phosphoserine Residue Binding Negative Regulation Of Peptidyl-serine Phosphorylation Galactosyltransferase Activity 3'-5' RNA Helicase Activity Golgi Trans Cisterna Disaccharide Metabolic Process Galactose Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Penetration Of Zona Pellucida Mitogen-activated Protein Kinase Kinase Binding Intestinal Epithelial Cell Development GTPase Activating Protein Binding Ubiquitin Ligase Activator Activity Epithelial Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Regulation Of Acrosome Reaction Negative Regulation Of Cell Fate Commitment	RNA Splicing MRNA Processing MRNA Metabolic Process Regulation Of MRNA Processing RNA Processing Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding
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