CDK11A and SKIC2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		CDK11A	SKIC2
Description		cyclin dependent kinase 11A	SKI2 subunit of superkiller complex
Image		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol Ski Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of Centrosome Cycle Regulation Of MRNA Processing Regulation Of Cell Cycle	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome
Pathways		Recruitment of mitotic centrosome proteins and complexes	Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease
Drugs
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		7 interacting genes: B4GALT1 CCNL1 GADD45A GADD45G PIN1 SKIC2 SPDEF	15 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 RHOU SNRPB TNRC17 TSSK2 WDR1 WEE2-AS1 XRN1
Entrez ID		728642	6499
HPRD ID			02724
Ensembl ID		ENSG00000008128	ENSG00000204351
Uniprot IDs		Q4VBY6 Q5QPR3 Q9UQ88	A0A1U9X8J1 A0A8V8TLC0 H7C5N0 Q15477
PDB IDs			7QDR 7QDS 7QDY 7QDZ 7QE0 9G8M 9G8N 9G8O 9G8P 9G8Q 9G8R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of P38MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of P38MAPK Cascade Regulation Of Cell Cycle Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Circulating Fibrinogen Levels Cis-trans Isomerase Activity Nuclear Speck Positive Regulation Of JNK Cascade Epithelial Cell Development Lactose Biosynthetic Process UDP-galactosyltransferase Activity Lactose Synthase Activity Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Lung Goblet Cell Differentiation Regulation Of JNK Cascade N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Regulation Of MAPK Cascade Glandular Epithelial Cell Development Development Of Secondary Sexual Characteristics Phosphoserine Residue Binding Negative Regulation Of Peptidyl-serine Phosphorylation Galactosyltransferase Activity 3'-5' RNA Helicase Activity Golgi Trans Cisterna Disaccharide Metabolic Process Galactose Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Penetration Of Zona Pellucida Mitogen-activated Protein Kinase Kinase Binding Intestinal Epithelial Cell Development GTPase Activating Protein Binding Ubiquitin Ligase Activator Activity Epithelial Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Regulation Of Acrosome Reaction Negative Regulation Of Cell Fate Commitment	Nuclear MRNA Surveillance Histone MRNA Catabolic Process Telomerase RNA Binding Histone MRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Maturation Of 5.8S RRNA U1 SnRNP Negative Regulation Of Telomere Maintenance Via Telomerase MRNA Catabolic Process Protein Serine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity 3'-5'-RNA Exonuclease Activity Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Serine/threonine Kinase Activity Regulation Of Membrane Repolarization Negative Regulation Of Telomere Maintenance Podosome Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization RNA Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Establishment Of Planar Polarity Of Follicular Epithelium Cellular Response To Puromycin Cellular Response To Cycloheximide Exonuclease Activity Protein Kinase Activity SnRNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening RRNA Metabolic Process Euchromatin Regulation Of Cell Morphogenesis Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of High Voltage-gated Calcium Channel Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Proline Dehydrogenase Activity
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