C5AR1 and WAS

Number of citations of the paper that reports this interaction (PubMedID 12600272)
69

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		C5AR1	WAS
Description		complement C5a receptor 1	WASP actin nucleation promoting factor
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GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Secretory Granule Membrane Cytoplasmic Vesicle Apical Part Of Cell	Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Membrane Site Of Double-strand Break Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding GTPase Regulator Activity Small GTPase Binding Identical Protein Binding Phospholipase Binding
	Biological Process	Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Signaling Neutrophil Chemotaxis Response To Peptidoglycan Complement Component C5a Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Angiogenesis Astrocyte Activation Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Cognition Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Amyloid-beta Clearance Presynapse Organization	Regulation Of T Cell Antigen Processing And Presentation Defense Response Immune Response Actin Filament Organization Rho Protein Signal Transduction Blood Coagulation Regulation Of Actin Polymerization Or Depolymerization Actin Polymerization Or Depolymerization Epidermis Development Regulation Of Lamellipodium Assembly Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Cdc42 Protein Signal Transduction T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Protein-containing Complex Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Motility Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Regulation of Complement cascade	Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Avacopan	(S)-wiskostatin
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Chronic periodontitis ( 25008200)	Platelet distribution width ( 32888494)
Interacting Genes		7 interacting genes: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS	61 interacting genes: ABI3 ACTC1 ACTR2 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CREBBP CRKL CSNK2A1 CSNK2A2 DLG1 DVL2 ENAH EVL FCHSD2 FGR FYB1 FYN GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RANBP2 RGS14 RHOJ RPA1 RPA2 RPA3 SNX9 SORBS2 SRC TCERG1 TEC TNK2 TRIP10 UBASH3A VASP WBP4 WIPF1 WIPF2
Entrez ID		728	7454
HPRD ID		00224	02314
Ensembl ID		ENSG00000197405	ENSG00000015285
Uniprot IDs		P21730	A0A8V8TM35 P42768
PDB IDs		2K3U 5O9H 6C1Q 6C1R 7Y64 7Y65 7Y66 7Y67 8GO8 8GOO 8HK5 8I0N 8I0Z 8IA2 8JZP 8JZZ	1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding Angiotensin Receptor Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway Chemotaxis Locomotion Regulation Of Immune Response G Protein-coupled Receptor Internalization Regulation Of Interleukin-6 Production Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Immune System Process Negative Regulation Of Leukocyte Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Receptor Internalization Cell Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune System Process Regulation Of ERK1 And ERK2 Cascade Regulation Of Cytokine Production Postsynaptic Signal Transduction Negative Regulation Of Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Leukocyte Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Locomotion Endocytic Vesicle Membrane Receptor Internalization Positive Regulation Of Metabolic Process Regulation Of Receptor Internalization Clathrin-coated Pit Negative Regulation Of Protein Ubiquitination Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Motility Regulation Of T Cell Antigen Processing And Presentation Regulation Of Locomotion Regulation Of Interleukin-8 Production Negative Regulation Of Post-translational Protein Modification Positive Regulation Of MAPK Cascade Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Innate Immune Response Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Vesicle-mediated Transport	Positive Regulation Of Actin Filament Polymerization Actin Filament Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Polymerization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Lamellipodium Supramolecular Fiber Organization Immune Response-activating Signaling Pathway Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Supramolecular Fiber Organization Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Size Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Cytosol Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Cytoplasm Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Immune System Process Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Cell Projection SH3 Domain Binding Regulation Of Immune System Process Phosphotyrosine Residue Binding Regulation Of Organelle Organization Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization
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