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C5AR1 and WAS
Number of citations of the paper that reports this interaction (PMID
12600272
)
2
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
C5AR1
WAS
Gene Name
complement component 5a receptor 1
Wiskott-Aldrich syndrome
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Cytoplasmic Membrane-bounded Vesicle
Basolateral Plasma Membrane
Apical Part Of Cell
Cytosol
Cell-cell Junction
Vesicle Membrane
Actin Cytoskeleton
Extracellular Vesicular Exosome
Molecular Function
Complement Component C5a Binding
Complement Component C5a Receptor Activity
C5a Anaphylatoxin Receptor Activity
Actin Binding
Small GTPase Regulator Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Identical Protein Binding
Phospholipase Binding
Biological Process
Activation Of MAPK Activity
Apoptotic Process
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
Signal Transduction
Activation Of Phospholipase C Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Sensory Perception Of Chemical Stimulus
Cell Proliferation In Hindbrain
Neutrophil Chemotaxis
Organ Regeneration
Response To Peptidoglycan
Response To Lipopolysaccharide
Complement Component C5a Signaling Pathway
MRNA Transcription From RNA Polymerase II Promoter
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epithelial Cell Proliferation
Defense Response To Gram-positive Bacterium
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Complex Assembly
Defense Response
Immune Response
Blood Coagulation
Actin Polymerization Or Depolymerization
Epidermis Development
Endosomal Transport
Actin Filament Polymerization
Actin Filament-based Movement
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
T Cell Activation
Innate Immune Response
Regulation Of Catalytic Activity
T Cell Receptor Signaling Pathway
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
TCR signaling
Generation of second messenger molecules
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
ARRB1
ARRB2
C5
C5AR2
GNAI2
RPS19
WAS
53 interactors:
ABI3
ACTC1
APBB1
APPBP2
ARHGAP1
ARHGEF7
ARPC1B
ARPC2
ARPC3
BAIAP2L1
BTK
C5AR1
CDC42
CIB1
CRKL
CSNK2A1
CSNK2A2
DLG1
ENAH
EVL
FCHSD2
FGR
FYB
FYN
GAS7
GRB2
HCK
HCLS1
ITK
ITSN2
LCK
LCP2
NCK1
NCK2
NCKIPSD
PIK3R1
PLCG1
PRPF40A
PSTPIP1
PTPN12
RAC1
RGS14
RHOJ
SORBS2
SRC
TCERG1
TEC
TNK2
TRIP10
VASP
WBP4
WIPF1
WIPF2
Entrez ID
728
7454
HPRD ID
00224
02314
Ensembl ID
ENSG00000197405
ENSG00000015285
Uniprot IDs
P21730
P42768
PDB IDs
1CEE
1EJ5
1T84
2A3Z
2K42
2OT0
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of MAPK Cascade
Negative Regulation Of Interleukin-6 Production
Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phosphorylation
Response To External Stimulus
Negative Regulation Of Leukocyte Chemotaxis
Negative Regulation Of Immune System Process
Regulation Of Interleukin-6 Production
Blood Coagulation
Hemostasis
Positive Regulation Of ERK1 And ERK2 Cascade
G-protein Coupled Receptor Internalization
Positive Regulation Of Signal Transduction
Regulation Of Cytokine Production
Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of Immune System Process
Regulation Of Phosphorylation
Positive Regulation Of Receptor Internalization
Regulation Of Body Fluid Levels
Cell Chemotaxis
Wound Healing
Chemotaxis
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Leukocyte Migration
Regulation Of Phosphorus Metabolic Process
Platelet Activation
Cell Activation
Negative Regulation Of Cytokine Production
Response To Wounding
Negative Regulation Of Chemotaxis
Positive Regulation Of Protein Phosphorylation
Regulation Of Receptor Internalization
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Catalytic Activity
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Endopeptidase Activity
Positive Regulation Of Receptor-mediated Endocytosis
Negative Regulation Of Innate Immune Response
Negative Regulation Of Peptidase Activity
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Metabolic Process
Regulation Of Immune Response
Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Response To Stress
Receptor Internalization
Positive Regulation Of Protein Modification Process
Negative Regulation Of Proteolysis
Negative Regulation Of Protein Processing
Regulation Of Protein Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Fc Receptor Signaling Pathway
Movement Of Cell Or Subcellular Component
Positive Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Locomotion
Axon Guidance
Regulation Of Immune Response
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Immune System Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Actin Filament Organization
Innate Immune Response
Chemotaxis
Positive Regulation Of Actin Filament Polymerization
Axonogenesis
Neuron Projection Morphogenesis
Immune Response
Positive Regulation Of Protein Polymerization
Enzyme Linked Receptor Protein Signaling Pathway
Axon Development
Actin Cytoskeleton Organization
Cell Morphogenesis Involved In Neuron Differentiation
Phagocytosis
Positive Regulation Of Protein Complex Assembly
Cell Morphogenesis Involved In Differentiation
Cytoskeleton Organization
Actin Filament-based Process
Regulation Of Actin Filament Polymerization
Cell Surface Receptor Signaling Pathway
Endocytosis
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Cytoskeleton Organization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Protein Complex Assembly
Regulation Of Actin Filament Length
Neuron Projection Development
Regulation Of Cellular Component Organization
Antigen Receptor-mediated Signaling Pathway
Cell Projection Morphogenesis
Cell Part Morphogenesis
Response To External Stimulus
Signal Transduction
T Cell Receptor Signaling Pathway
Signaling
Tagcloud
?
10d
a2a
adenosine
adora1
adora2a
adora3
b4
calving
chemoattractant
deaminase
holstein
hydroxybutyrate
leukotriene
ltb4r
mcal
multiparous
nonesterified
nucleotidase
p2ry2
p2y
parturition
peripartal
pmnl
ptafr
purinergic
sell
selplg
slc29a1
slc29a2
Tagcloud (Difference)
?
10d
a2a
adenosine
adora1
adora2a
adora3
b4
calving
chemoattractant
deaminase
holstein
hydroxybutyrate
leukotriene
ltb4r
mcal
multiparous
nonesterified
nucleotidase
p2ry2
p2y
parturition
peripartal
pmnl
ptafr
purinergic
sell
selplg
slc29a1
slc29a2
Tagcloud (Intersection)
?