C5AR1 and RPS19

Number of citations of the paper that reports this interaction (PMID 11733378)
6

Data Source:
HPRD (in vivo)

		C5AR1	RPS19
Gene Name		complement component 5a receptor 1	ribosomal protein S19
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cytoplasmic Membrane-bounded Vesicle Basolateral Plasma Membrane Apical Part Of Cell	Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Complement Component C5a Binding Complement Component C5a Receptor Activity C5a Anaphylatoxin Receptor Activity	Structural Constituent Of Ribosome Protein Binding Fibroblast Growth Factor Binding Protein Kinase Binding Protein Homodimerization Activity Poly(A) RNA Binding
	Biological Process	Activation Of MAPK Activity Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Cell Proliferation In Hindbrain Neutrophil Chemotaxis Organ Regeneration Response To Peptidoglycan Response To Lipopolysaccharide Complement Component C5a Signaling Pathway MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade	Ribosomal Small Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Monocyte Chemotaxis RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Nucleolus Organization Response To Extracellular Stimulus Gene Expression Viral Process Viral Life Cycle Viral Transcription Erythrocyte Differentiation Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis Cellular Protein Metabolic Process Protein Tetramerization Positive Regulation Of Cellular Component Movement Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS	5 interactors: APP C5AR1 FGF2 RPS19BP1 TXNDC11
Entrez ID		728	6223
HPRD ID		00224	04591
Ensembl ID		ENSG00000197405	ENSG00000105372
Uniprot IDs		P21730	B0ZBD0 P39019
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAPK Cascade Negative Regulation Of Interleukin-6 Production Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To External Stimulus Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Immune System Process Regulation Of Interleukin-6 Production Blood Coagulation Hemostasis Positive Regulation Of ERK1 And ERK2 Cascade G-protein Coupled Receptor Internalization Positive Regulation Of Signal Transduction Regulation Of Cytokine Production Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Immune System Process Regulation Of Phosphorylation Positive Regulation Of Receptor Internalization Regulation Of Body Fluid Levels Cell Chemotaxis Wound Healing Chemotaxis Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Migration Regulation Of Phosphorus Metabolic Process Platelet Activation Cell Activation Negative Regulation Of Cytokine Production Response To Wounding Negative Regulation Of Chemotaxis Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Cell Surface Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Endopeptidase Activity Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Innate Immune Response Negative Regulation Of Peptidase Activity Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Metabolic Process Regulation Of Immune Response Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Stress Receptor Internalization Positive Regulation Of Protein Modification Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Phosphorylation	Cellular Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Homeostatic Process Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Phospholipase C Activity Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Phospholipase Activity Chemotaxis Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Complement Component C5a Signaling Pathway Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Chemical Homeostasis Activation Of MAPK Activity Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hydrolase Activity Cytosolic Calcium Ion Homeostasis Regulation Of Protein Phosphorylation Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Locomotion Immune Response Regulation Of Phosphorylation Defense Response Collateral Sprouting Axon Midline Choice Point Recognition Cell Proliferation In Hindbrain Complement Receptor Mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Epithelial Cell Proliferation Regulation Of Developmental Growth Regulation Of MAP Kinase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cell Fate Specification
Tagcloud ?		10d a2a adenosine adora1 adora2a adora3 b4 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2	apocytochrome infa l20 l22 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl2 rpl20 rpl22 rpl23 rpl33 rpoa rps11 rps12 rps18 rps3 rps8 secx ugg
Tagcloud (Difference) ?		10d a2a adenosine adora1 adora2a adora3 b4 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2	apocytochrome infa l20 l22 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl2 rpl20 rpl22 rpl23 rpl33 rpoa rps11 rps12 rps18 rps3 rps8 secx ugg
Tagcloud (Intersection) ?