C5AR1 and C5AR2

Number of citations of the paper that reports this interaction (PMID 17322907)
51

Data Source:
HPRD (in vivo, in vitro)

		C5AR1	C5AR2
Gene Name		complement component 5a receptor 1	complement component 5a receptor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cytoplasmic Membrane-bounded Vesicle Basolateral Plasma Membrane Apical Part Of Cell	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Complement Component C5a Binding Complement Component C5a Receptor Activity C5a Anaphylatoxin Receptor Activity	C5a Anaphylatoxin Receptor Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Cell Proliferation In Hindbrain Neutrophil Chemotaxis Organ Regeneration Response To Peptidoglycan Response To Lipopolysaccharide Complement Component C5a Signaling Pathway MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade	Chemotaxis Inflammatory Response G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Interleukin-6 Secretion Regulation Of Interleukin-8 Secretion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS	3 interactors: C3 C4A C5AR1
Entrez ID		728	27202
HPRD ID		00224	17072
Ensembl ID		ENSG00000197405	ENSG00000134830
Uniprot IDs		P21730	Q9P296
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAPK Cascade Negative Regulation Of Interleukin-6 Production Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To External Stimulus Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Immune System Process Regulation Of Interleukin-6 Production Blood Coagulation Hemostasis Positive Regulation Of ERK1 And ERK2 Cascade G-protein Coupled Receptor Internalization Positive Regulation Of Signal Transduction Regulation Of Cytokine Production Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Immune System Process Regulation Of Phosphorylation Positive Regulation Of Receptor Internalization Regulation Of Body Fluid Levels Cell Chemotaxis Wound Healing Chemotaxis Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Migration Regulation Of Phosphorus Metabolic Process Platelet Activation Cell Activation Negative Regulation Of Cytokine Production Response To Wounding Negative Regulation Of Chemotaxis Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Cell Surface Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Endopeptidase Activity Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Innate Immune Response Negative Regulation Of Peptidase Activity Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Metabolic Process Regulation Of Immune Response Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Stress Receptor Internalization Positive Regulation Of Protein Modification Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Phosphorylation	Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Regulation Of Complement Activation Inflammatory Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Regulation Of Phagocytosis Regulation Of Acute Inflammatory Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Endocytosis Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Complement Component C5a Signaling Pathway Protein Activation Cascade Immune Response Immunoglobulin Mediated Immune Response Regulation Of Immune System Process B Cell Mediated Immunity Regulation Of Endocytosis Defense Response Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Endopeptidase Activity Leukocyte Mediated Immunity Adaptive Immune Response Negative Regulation Of Peptidase Activity Regulation Of Inflammatory Response Positive Regulation Of Activation Of Membrane Attack Complex Cell Proliferation In Hindbrain Complement Receptor Mediated Signaling Pathway Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Vesicle-mediated Transport Immune System Process Regulation Of Endopeptidase Activity Positive Regulation Of Hypersensitivity Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Catalytic Activity Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus MRNA Transcription From RNA Polymerase II Promoter
Tagcloud ?		10d a2a adenosine adora1 adora2a adora3 b4 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Difference) ?		10d a2a adenosine adora1 adora2a adora3 b4 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Intersection) ?