NAPA and RTN4

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NAPA	RTN4
Description		NSF attachment protein alpha	reticulon 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Neuromuscular Junction Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Membrane Cell Junction Cell Projection Neuron Projection Neuronal Cell Body Synapse Anchoring Junction Endoplasmic Reticulum Tubular Network Postsynapse Endoplasmic Reticulum Tubular Network Membrane Glutamatergic Synapse
	Molecular Function	SNARE Binding Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding Protein-containing Complex Binding	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Brain Development Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Vesicle-mediated Transport Neuron Differentiation Protein-containing Complex Disassembly Synaptic Transmission, Glutamatergic SNARE Complex Disassembly Apical Protein Localization Membrane Fusion	Blastocyst Formation Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Endoplasmic Reticulum Organization Nervous System Development Axonal Fasciculation Brain Development Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia-guided Migration Central Nervous System Vasculogenesis Neuron Differentiation Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Rac Protein Signal Transduction Cell Migration Involved In Vasculogenesis Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Modulation Of Chemical Synaptic Transmission Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Nervous System Development Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Cellular Response To Hypoxia Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Intracellular Sphingolipid Homeostasis Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Neutrophil Migration Positive Regulation Of Macrophage Migration Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Positive Regulation Of Artery Morphogenesis Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Vasculogenesis
Pathways		COPII-mediated vesicle transport Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Adult body size ( 32376654) Fasting glucose ( 34074324) Lymphocyte count ( 32888494) Obesity (extreme) ( 19553259) Platelet count ( 32888494) Systolic blood pressure ( 30224653 32902719)
Interacting Genes		22 interacting genes: APP BNIP1 DSCAM FURIN GNA12 GOSR1 GOSR2 HSPB1 HUNK NSF RIPK4 RTN4 SNAP23 SNAP25 STX12 STX1A STX4 STX5 STX7 STX8 TRPC3 VAMP8	49 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 OGT PLEKHF2 POT1 PRR13 RAB33A RNF10 RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21
Entrez ID		8775	57142
HPRD ID		04447	07259
Ensembl ID		ENSG00000105402	ENSG00000115310
Uniprot IDs		P54920	Q9NQC3
PDB IDs			2G31 2JV5
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Organelle Membrane Fusion Membrane Fusion Organelle Fusion Vesicle Fusion SNARE Binding Membrane Organization Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Docking Vesicle-mediated Transport Establishment Of Localization In Cell Chloride Channel Inhibitor Activity Protein Transport Syntaxin Binding Establishment Of Protein Localization Secretion By Cell Endomembrane System Intracellular Protein Localization Organelle Localization Intracellular Transport Vesicle Neuron Projection Secretion Exocytosis Intracellular Protein Transport SNARE Complex Assembly Recycling Endosome Cellular Localization Golgi Vesicle Transport Plasma Membrane Endosome Organelle Organization Membrane Neurotransmitter Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Intra-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Neuron Recognition Modulation Of Chemical Synaptic Transmission Positive Regulation Of Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of Regulated Secretory Pathway Protein-containing Complex Organization Heparan Sulfate Binding Regulation Of Protein Localization To Cell Periphery	Neuregulin Receptor Activity Membrane Organization Signal Transduction G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Presynapse ERBB3:ERBB2 Complex Glutamatergic Synapse Cell Projection Morphogenesis Dendritic Cell Apoptotic Process Membrane Neuromuscular Process Neuron Differentiation Response To Epidermal Growth Factor Protein Localization To Synapse Regulation Of Synapse Organization ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Rho Protein Signal Transduction ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway BH3 Domain Binding Cell Surface Receptor Signaling Pathway Cell Junction Organization Myelin Sheath Axonogenesis ERBB Signaling Pathway Endosome Neuromuscular Junction Non-canonical Inflammasome Complex Assembly Shelterin Complex Neuronal Signal Transduction Protein Localization To Cell Junction Mitochondrion Organization Cell Junction Assembly Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Projection Morphogenesis Signaling Receptor Activity Myelination Axon Ensheathment Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Establishment Of Localization In Cell Regulation Of ERK1 And ERK2 Cascade GABA-ergic Synapse Positive Regulation Of ERK1 And ERK2 Cascade Ceramide Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?