NAPA and SNAP25

Number of citations of the paper that reports this interaction (PMID 7622514)
44

Data Source:
BioGRID (pull down)

		NAPA	SNAP25
Gene Name		N-ethylmaleimide-sensitive factor attachment protein, alpha	synaptosomal-associated protein, 25kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Vacuolar Membrane Cytosol Membrane SNARE Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Vesicular Exosome	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
	Molecular Function	Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Brain Development Regulation Of Synaptic Vesicle Priming Neuron Differentiation Synaptic Transmission, Glutamatergic SNARE Complex Disassembly Apical Protein Localization Membrane Organization Membrane Fusion	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Botulinum Toxin Type A
Diseases
GWAS			Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		17 interactors: APP BNIP1 GNA12 GOSR1 GOSR2 NSF RTN4 SNAP23 SNAP25 STX12 STX1A STX4 STX5 STX7 STX8 TRPC3 VAMP8	34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17
Entrez ID		8775	6616
HPRD ID		04447	02637
Ensembl ID		ENSG00000105402	ENSG00000132639
Uniprot IDs		P54920	P60880
PDB IDs			1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR
Enriched GO Terms of Interacting Partners?		Membrane Fusion Organelle Fusion Vesicle Fusion Vesicle Organization Membrane Organization Vesicle-mediated Transport Vesicle Docking Membrane Docking Establishment Of Localization In Cell Intracellular Transport Synaptic Vesicle Fusion To Presynaptic Membrane Cellular Localization Protein Transport Golgi Vesicle Transport Establishment Of Protein Localization Exocytosis Post-Golgi Vesicle-mediated Transport Transport Protein Localization Secretion By Cell Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Exocytosis Intracellular Protein Transport Organelle Organization Secretion Regulation Of Cellular Localization Neurotransmitter Secretion Synaptic Vesicle Transport Cellular Protein Localization Regulation Of Cellular Component Organization Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Neurotransmitter Transport Intra-Golgi Vesicle-mediated Transport Organelle Localization Platelet Activation Positive Regulation Of Exocytosis Establishment Of Vesicle Localization Regulation Of Protein Localization Endosomal Transport Vesicle Localization Retrograde Transport, Endosome To Golgi Synaptic Vesicle Docking Vesicle Fusion With Golgi Apparatus SNARE Complex Assembly Synaptic Vesicle Priming Regulation Of Hormone Secretion Regulation Of Body Fluid Levels ER To Golgi Vesicle-mediated Transport Synaptic Transmission	Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion
Tagcloud ?		account activate alter beta cat construct contains cotransfected delta demonstrating element half independence inducing neuroblastoma phenylacetate promoting ra rar rare re reporter retinoic sodium sv synergize synergy upregulating vector	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Difference) ?		account activate alter beta cat construct contains cotransfected delta demonstrating element half independence inducing neuroblastoma phenylacetate promoting ra rar rare re reporter retinoic sodium sv synergize synergy upregulating vector	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Intersection) ?