NAPA and SNAP23

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		NAPA	SNAP23
Description		NSF attachment protein alpha	synaptosome associated protein 23
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Neuromuscular Junction Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Mitochondrion Plasma Membrane Adherens Junction Focal Adhesion Cilium Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Specific Granule Membrane Specific Granule Azurophil Granule Neuron Projection Synapse Extracellular Exosome Tertiary Granule Membrane Presynapse
	Molecular Function	SNARE Binding Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding Protein-containing Complex Binding	SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Brain Development Regulation Of Synaptic Vesicle Priming Protein Transport Synaptic Vesicle Priming Vesicle-mediated Transport Neuron Differentiation Protein-containing Complex Disassembly Synaptic Transmission, Glutamatergic SNARE Complex Disassembly Apical Protein Localization Membrane Fusion	Histamine Secretion By Mast Cell Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Targeting Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Membrane Fusion
Pathways		COPII-mediated vesicle transport Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Bipolar disorder ( 31043756)
Interacting Genes		22 interacting genes: APP BNIP1 DSCAM FURIN GNA12 GOSR1 GOSR2 HSPB1 HUNK NSF RIPK4 RTN4 SNAP23 SNAP25 STX12 STX1A STX4 STX5 STX7 STX8 TRPC3 VAMP8	32 interacting genes: ABI2 ABI3 CFTR FXR2 ITSN1 KIF5B MATR3 NAPA NAPB PRKCA SCAMP1 SCAMP2 SCGN SNAPIN SNTG1 STX11 STX12 STX1A STX1B STX3 STX4 STX5 STX6 STXBP2 STXBP5 TLK1 VAMP1 VAMP2 VAMP3 VAMP7 VAMP8 WASH2P
Entrez ID		8775	8773
HPRD ID		04447	03962
Ensembl ID		ENSG00000105402	ENSG00000092531
Uniprot IDs		P54920	A8K287 O00161
PDB IDs			1NHL 3ZUS
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex Organelle Membrane Fusion Membrane Fusion Organelle Fusion Vesicle Fusion SNARE Binding Membrane Organization Organelle Localization By Membrane Tethering Vesicle Organization Membrane Docking Vesicle Docking Vesicle-mediated Transport Establishment Of Localization In Cell Chloride Channel Inhibitor Activity Protein Transport Syntaxin Binding Establishment Of Protein Localization Secretion By Cell Endomembrane System Intracellular Protein Localization Organelle Localization Intracellular Transport Vesicle Neuron Projection Secretion Exocytosis Intracellular Protein Transport SNARE Complex Assembly Recycling Endosome Cellular Localization Golgi Vesicle Transport Plasma Membrane Endosome Organelle Organization Membrane Neurotransmitter Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Intra-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Neuron Recognition Modulation Of Chemical Synaptic Transmission Positive Regulation Of Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of Regulated Secretory Pathway Protein-containing Complex Organization Heparan Sulfate Binding Regulation Of Protein Localization To Cell Periphery	SNARE Complex SNAP Receptor Activity Vesicle Fusion Organelle Membrane Fusion Membrane Fusion Organelle Fusion SNARE Binding Exocytosis Organelle Localization By Membrane Tethering Membrane Docking Vesicle Docking Protein Transport Establishment Of Protein Localization Vesicle-mediated Transport Secretion By Cell Vesicle Organization Secretion Membrane Organization Establishment Of Localization In Cell Intracellular Protein Localization SNARE Complex Assembly Syntaxin Binding Organelle Localization Intracellular Protein Transport Regulation Of Exocytosis Cellular Localization Intracellular Transport Regulation Of Synaptic Vesicle Priming Regulation Of Vesicle-mediated Transport Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Secretion By Cell Regulated Exocytosis Calcium-ion Regulated Exocytosis Endomembrane System Regulation Of Secretion Zymogen Granule Membrane Phagocytic Vesicle Positive Regulation Of Exocytosis Neutrophil Degranulation Regulation Of Histamine Secretion By Mast Cell Vesicle-mediated Transport In Synapse Neuron Projection Recycling Endosome Membrane Secretory Granule Regulation Of Hormone Secretion Golgi Vesicle Transport Positive Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Synaptic Vesicle Exocytosis Synaptic Vesicle Membrane
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