COMMD3 and PIH1D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COMMD3	PIH1D2
Description		COMM domain containing 3	PIH1 domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Ficolin-1-rich Granule Lumen	Cytoplasm R2TP Complex Protein Folding Chaperone Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport	Box C/D SnoRNP Assembly RRNA Processing Protein Stabilization
Pathways		Neutrophil degranulation Neddylation
Drugs
Diseases
GWAS		Prostate-specific antigen levels ( 28139693)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: COMMD1 PIH1D2 TRAF5 ZNF337	69 interacting genes: ANKRD11 BAG3 BANP CBLL2 CBX8 CCNL2 CDC23 CDCA8 CDKL3 CFAP206 COMMD3 CT55 CTAG1A CTAG1B DES DPH3 DSCAM EIF4A2 EXOSC5 FRS3 GFAP GMCL1 GPRASP2 HES7 HSF4 IGF2BP3 IQUB ITGB3BP KRTAP12-2 KRTAP12-4 LAP3 LMNB1 MCCD1 MDFI MED20 MISP MRFAP1L1 MVP NFIL3 NHSL2 NOTO NTAQ1 NXF1 PBX4 PLEKHJ1 POLR1C PRDM6 PRMT3 RALA REL RSPO4 SDCBP SERTAD1 SLPI SPRED1 SSX3 SUOX TAF6 TASOR2 TBATA TCEA2 TNNI1 TTC23 ZBTB1 ZMAT5 ZNF185 ZNF417 ZNF438 ZNF688
Entrez ID		23412	120379
HPRD ID		13082	14021
Ensembl ID		ENSG00000148444	ENSG00000150773
Uniprot IDs		Q9UBI1	Q8WWB5
PDB IDs		8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-binding Transcription Factor Activity R2TP Complex Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Regulation Of Plasma Lipoprotein Particle Levels Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Regulation Of Protein Stability Box C/D SnoRNP Assembly Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Plasma Membrane To Endosome Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Sodium Ion Transport Low-density Lipoprotein Particle Clearance Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling Regulation Of Cellular Response To Hypoxia Phosphatidic Acid Binding	Protein Binding Nucleus
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