TPM4 and SNAPIN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TPM4	SNAPIN
Description		tropomyosin 4	SNAP associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Podosome Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Cortical Cytoskeleton Extracellular Exosome	Golgi Membrane Acrosomal Vesicle Manchette Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Synaptic Vesicle Membrane Secretory Granule Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm Microvesicle
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Actin Filament Binding	SNARE Binding Protein Binding
	Biological Process	Osteoblast Differentiation Muscle Contraction Actin Filament Organization Platelet Formation	Intracellular Protein Transport Exocytosis Lysosome Organization Lysosomal Lumen Acidification Chemical Synaptic Transmission Neurotransmitter Secretion Anterograde Axonal Transport Retrograde Axonal Transport Endosome To Lysosome Transport Negative Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Neuron Projection Development Protein-containing Complex Localization Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Melanosome Organization Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Protein Maturation Establishment Of Vesicle Localization Regulation Of Lysosome Size Neuron Cellular Homeostasis Organelle Transport Along Microtubule Terminal Button Organization Autophagosome Maturation Late Endosome To Lysosome Transport Positive Regulation Of Late Endosome To Lysosome Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways		Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants	Golgi Associated Vesicle Biogenesis
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Longevity ( 33657282) Mean platelet volume ( 22139419 22423221 27863252 31080455 32888494) Platelet count ( 22139419 22423221 26805783 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		12 interacting genes: DANCR ISG15 JRK LNX1 NOD2 PACSIN1 PDE4B PICK1 SNAPIN TCERG1 TRIP6 USP7	103 interacting genes: ABI2 ACTN2 ATG14 ATP1A1 BANP BFSP1 BFSP2 BIN1 BLOC1S1 BLOC1S2 BLOC1S4 BLOC1S5 BLOC1S6 BNIPL C20orf202 CCDC102B CDC42BPA CEP170 CMYA5 CSNK1D DDR1 DENND1C DES DNM2 DOCK9 DST DTNBP1 DYRK3 DYSF EBAG9 EEF1G ELP1 ENO3 EXOC7 FAM114A1 FSD2 GPRASP1 GRIK1 HAP1 HMGB2 IKBIP IMMT KANK2 KAT5 KAT7 KIF5C KPNB1 KRT10 KRT15 KRT16 KRT17 KRT19 KRT20 KRT24 KRT26 LAMA2 LAMC1 LMNB1 LRP12 MACF1 MAPK14 MET MORC3 MTNR1A MYH14 MYH3 MYH7 NECAB2 NEDD9 NME7 NUP62CL PCYT1A PLAC9 PLEC PRKACA RABEP1 RABGEF1 RETREG1 RGS7 RNF13 SHBG SKA1 SMAD2 SMG1 SNAP23 SNAP25 SPAG5 SPP1 SPTB SPTBN1 ST7 TFIP11 TOMM70 TPM1 TPM2 TPM3 TPM4 TRIM63 TRPV1 TSG101 WASHC3 YWHAE YWHAZ
Entrez ID		7171	23557
HPRD ID		11734	06111
Ensembl ID		ENSG00000167460	ENSG00000143553
Uniprot IDs		A0A2R8Y5V9 K7ENT6 P67936 V9HW56	O95295
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Regulation Of Cell Communication Vesicle-mediated Transport In Synapse Regulation Of Signaling Cellular Response To Epinephrine Stimulus Regulation Of Vesicle-mediated Transport Response To Epinephrine Regulation Of Transport Regulation Of Autophagy Regulation Of Establishment Of Protein Localization Cytoplasm Ciliary Base Intracellular Protein Transport Modulation Of Chemical Synaptic Transmission Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Nutrient Levels Developmental Maturation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Late Endosome To Lysosome Transport Presynaptic Endocytic Zone Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Regulation Of Gluconeogenesis Regulation Of Interleukin-2 Production Protein Modification Process Cellular Response To Nutrient Levels Regulation Of Intracellular Transport TORC1 Signaling Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Protein Ubiquitination Regulation Of Interleukin-10 Production Negative Regulation Of TORC1 Signaling Protein-containing Complex Localization Membrane Organization Golgi Vesicle Fusion To Target Membrane Positive Regulation Of Type II Interferon Production Negative Regulation Of Relaxation Of Cardiac Muscle Detection Of Peptidoglycan Intracellular Protein Localization Protein Localization To Membrane Regulation Of Cardiac Muscle Contraction Regulation Of Endocytosis Protein Modification By Small Protein Conjugation Perinuclear Region Of Cytoplasm Phagocytic Vesicle TOR Signaling Neuron Projection Cytosol Negative Regulation Of TOR Signaling	Cytoskeleton Organization Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Organization Establishment Of Organelle Localization Intermediate Filament Supramolecular Fiber Organization Organelle Localization Structural Constituent Of Cytoskeleton BLOC-1 Complex Actin Filament Binding Synaptic Vesicle Transport Establishment Of Vesicle Localization Structural Molecule Activity Axo-dendritic Transport Axon Cytoplasm Axonal Transport Vesicle Localization Establishment Of Localization In Cell Anterograde Axonal Transport Cytosol Anterograde Synaptic Vesicle Transport Muscle Thin Filament Tropomyosin Structural Constituent Of Skin Epidermis Cytoplasm Transport Along Microtubule Vesicle Transport Along Microtubule Cellular Localization Cytoskeleton-dependent Intracellular Transport Vesicle Cytoskeletal Trafficking Regulation Of Cellular Component Organization Microtubule-based Transport Melanosome Organization Keratin Filament Intracellular Transport Pigment Granule Organization Structural Constituent Of Muscle Actomyosin Structure Organization Muscle System Process Actin Binding Muscle Contraction Extracellular Exosome Contractile Muscle Fiber Stress Fiber Organelle Transport Along Microtubule Tissue Morphogenesis Intracellular Protein Localization Z Disc
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