TPM4 and PACSIN1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		TPM4	PACSIN1
Gene Name		tropomyosin 4	protein kinase C and casein kinase substrate in neurons 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Podosome Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Focal Adhesion Membrane Cortical Cytoskeleton Filamentous Actin Extracellular Vesicular Exosome	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Cell Junction COPI-coated Vesicle Cytoplasmic Vesicle Membrane Membrane-bounded Vesicle Ruffle Membrane Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Calcium Ion Binding Structural Constituent Of Muscle	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding
	Biological Process	Osteoblast Differentiation Movement Of Cell Or Subcellular Component Muscle Contraction Muscle Filament Sliding	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Establishment Of Protein Localization To Plasma Membrane Membrane Tubulation Positive Regulation Of Dendrite Development
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419 22423221) Platelet counts ( 22139419)
Protein-Protein Interactions		5 interactors: LNX1 PACSIN1 TCERG1 TPM1 TRIP6	24 interactors: ANKRD24 ARHGAP17 ATP8 COBL COBLL1 DNM1 EHBP1 FTH1 GAS7 HTT JADE2 KAT7 KHDRBS1 PACSIN2 PACSIN3 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL
Entrez ID		7171	29993
HPRD ID		11734	05936
Ensembl ID		ENSG00000167460	ENSG00000124507
Uniprot IDs		P67936	Q5TZC3 Q9BY11
PDB IDs			3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?			Cell Projection Morphogenesis Cell Part Morphogenesis Actin Filament-based Process Endocytosis Cellular Component Assembly Vesicle-mediated Transport Cell Morphogenesis Regulation Of Cellular Component Organization Organelle Organization Cytoskeleton Organization Cell Projection Organization Actin Cytoskeleton Organization Neuron Development Neuron Projection Morphogenesis Regulation Of Endocytosis Actin Filament-based Movement Endomembrane System Organization Generation Of Neurons Neuron Differentiation Histone H4-K12 Acetylation Membrane Tubulation Neurogenesis Neuron Projection Development Actin Polymerization Or Depolymerization Histone H4-K5 Acetylation Histone H4-K8 Acetylation Membrane Organization Axonogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Protein Polymerization Anatomical Structure Morphogenesis Axon Development Regulation Of Cellular Process Regulation Of Protein Depolymerization Positive Regulation Of Protein Depolymerization Actin Filament Organization Cell Morphogenesis Involved In Neuron Differentiation Membrane Assembly Regulation Of Cell Projection Assembly Regulation Of Protein Complex Disassembly Protein Complex Assembly Movement Of Cell Or Subcellular Component Cellular Protein Complex Assembly Membrane Biogenesis Cell Differentiation Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Complex Disassembly Cell Morphogenesis Involved In Differentiation Axon Guidance
Tagcloud ?		12q alk backgroundthe ccnd3 conclusionsour ews fli1 foxo1 fusion fusions harbor inactivating kcnmb4 lrp1 methodstranscriptome opportunities osteosarcoma osteosarcomas pax3 resultsnine sanger saos sarcomas snrnp25 ssx1 ssx2 syt tpm3 transcriptome	10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2
Tagcloud (Difference) ?		12q alk backgroundthe ccnd3 conclusionsour ews fli1 foxo1 fusion fusions harbor inactivating kcnmb4 lrp1 methodstranscriptome opportunities osteosarcoma osteosarcomas pax3 resultsnine sanger saos sarcomas snrnp25 ssx1 ssx2 syt tpm3 transcriptome	10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2
Tagcloud (Intersection) ?