TPM4 and ISG15

Number of citations of the paper that reports this interaction (PubMedID 34599178)
110

Data Source:
BioGRID (pull down)

		TPM4	ISG15
Description		tropomyosin 4	ISG15 ubiquitin like modifier
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Podosome Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Cortical Cytoskeleton Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Actin Filament Binding	Integrin Binding Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Osteoblast Differentiation Muscle Contraction Actin Filament Organization Platelet Formation	Immune System Process Regulation Of Immune System Process Integrin-mediated Signaling Pathway Response To Virus Response To Bacterium Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Protein Oligomerization Regulation Of Type II Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Protein Localization To Mitochondrion
Pathways		Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Longevity ( 33657282) Mean platelet volume ( 22139419 22423221 27863252 31080455 32888494) Platelet count ( 22139419 22423221 26805783 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494)	Blood protein levels ( 30072576)
Interacting Genes		12 interacting genes: DANCR ISG15 JRK LNX1 NOD2 PACSIN1 PDE4B PICK1 SNAPIN TCERG1 TRIP6 USP7	25 interacting genes: BRAP CBX5 DDOST FUS GRPEL1 HDAC6 HIF1A KLHL26 MRTO4 NAP1L1 NCL PFN1 RPL23 RPL3 RPN2 SUMO1 TPM3 TPM4 TUBA1B UBA7 USP14 USP16 USP18 USP21 USP5
Entrez ID		7171	9636
HPRD ID		11734	00958
Ensembl ID		ENSG00000167460	ENSG00000187608
Uniprot IDs		A0A2R8Y5V9 K7ENT6 P67936 V9HW56	P05161
PDB IDs			1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9 7RBS 7S6P 8OIF 8SE9 8SEA 8SEB 8SV8
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Regulation Of Cell Communication Vesicle-mediated Transport In Synapse Regulation Of Signaling Cellular Response To Epinephrine Stimulus Regulation Of Vesicle-mediated Transport Response To Epinephrine Regulation Of Transport Regulation Of Autophagy Regulation Of Establishment Of Protein Localization Cytoplasm Ciliary Base Intracellular Protein Transport Modulation Of Chemical Synaptic Transmission Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Nutrient Levels Developmental Maturation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Late Endosome To Lysosome Transport Presynaptic Endocytic Zone Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Regulation Of Gluconeogenesis Regulation Of Interleukin-2 Production Protein Modification Process Cellular Response To Nutrient Levels Regulation Of Intracellular Transport TORC1 Signaling Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Protein Ubiquitination Regulation Of Interleukin-10 Production Negative Regulation Of TORC1 Signaling Protein-containing Complex Localization Membrane Organization Golgi Vesicle Fusion To Target Membrane Positive Regulation Of Type II Interferon Production Negative Regulation Of Relaxation Of Cardiac Muscle Detection Of Peptidoglycan Intracellular Protein Localization Protein Localization To Membrane Regulation Of Cardiac Muscle Contraction Regulation Of Endocytosis Protein Modification By Small Protein Conjugation Perinuclear Region Of Cytoplasm Phagocytic Vesicle TOR Signaling Neuron Projection Cytosol Negative Regulation Of TOR Signaling	Cysteine-type Deubiquitinase Activity Protein Deubiquitination Regulation Of Protein Stability Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Presynaptic Cytosol Muscle Thin Filament Tropomyosin Oligosaccharyltransferase Complex B Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Oligosaccharyltransferase Complex A Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Epithelial Cell Migration Oligosaccharyltransferase Complex Negative Regulation Of Catabolic Process Axonal Transport Of Mitochondrion Adenyl-nucleotide Exchange Factor Activity Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleolus Peptidase Activity Ubiquitin Binding Cellular Response To Interleukin-4 Deubiquitinase Activity Protein K48-linked Deubiquitination Mitochondrion Transport Along Microtubule Response To Interleukin-4 Postsynaptic Cytosol Histone Deacetylase Binding Response To Cytokine RNA Binding Regulation Of Protein Metabolic Process Establishment Of Mitochondrion Localization Response To Peptide Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process ISG15 Activating Enzyme Activity Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis Hsp90 Protein Binding
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