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FBXO5 and ANAPC7
Number of citations of the paper that reports this interaction (PMID
16921029
)
58
Data Source:
BioGRID
(affinity chromatography technology, pull down)
FBXO5
ANAPC7
Gene Name
F-box protein 5
anaphase promoting complex subunit 7
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Spindle
Cytosol
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Protein Binding
Protein Kinase Binding
Metal Ion Binding
Protein Phosphatase Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Oocyte Maturation
Spindle Assembly Involved In Female Meiosis I
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Vesicle Organization
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Meiotic Nuclear Division
Microtubule Polymerization
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Inhibition Of APC-Cdc20 Complex Activity
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cell Division
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Protein K11-linked Ubiquitination
Pathways
E2F mediated regulation of DNA replication
G1/S Transition
G1/S-Specific Transcription
SCF-beta-TrCP mediated degradation of Emi1
Regulation of mitotic cell cycle
Mitotic Metaphase/Anaphase Transition
Phosphorylation of Emi1
Regulation of APC/C activators between G1/S and early anaphase
Mitotic G1-G1/S phases
M Phase
Mitotic Metaphase and Anaphase
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
Phosphorylation of the APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Antigen processing: Ubiquitination & Proteasome degradation
Separation of Sister Chromatids
Inactivation of APC/C via direct inhibition of the APC/C complex
Cellular Senescence
Mitotic Anaphase
APC/C:Cdc20 mediated degradation of Securin
M Phase
Inactivation of APC/C via direct inhibition of the APC/C complex
Autodegradation of Cdh1 by Cdh1:APC/C
Mitotic Spindle Checkpoint
Class I MHC mediated antigen processing & presentation
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Cell Cycle, Mitotic
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Cell Cycle Checkpoints
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
16 interactors:
ANAPC1
ANAPC11
ANAPC2
ANAPC4
ANAPC5
ANAPC7
BTRC
CDC16
CDC20
CDC23
CDC27
CDK1
EVI5
FZR1
SKP1
TPM3
14 interactors:
ANAPC10
ANAPC2
ANAPC4
BUB1B
CDC16
CDC20
CDC27
CDH1
CDT1
CREBBP
FBXO5
FZR1
UBC
UBE2S
Entrez ID
26271
51434
HPRD ID
09348
16233
Ensembl ID
ENSG00000112029
ENSG00000196510
Uniprot IDs
Q9UKT4
Q4KMX6
Q69YV3
Q9UJX3
PDB IDs
2M6N
3FFL
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Protein K11-linked Ubiquitination
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Ubiquitin-protein Transferase Activity
Spindle Assembly Checkpoint
Positive Regulation Of Proteolysis
Mitotic Spindle Checkpoint
Negative Regulation Of Chromosome Segregation
Spindle Checkpoint
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Negative Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Cell Division
Cell Cycle Checkpoint
Regulation Of Chromosome Segregation
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Positive Regulation Of Transferase Activity
Negative Regulation Of Chromosome Organization
Mitotic Cell Cycle Checkpoint
Protein Catabolic Process
Protein Polyubiquitination
Cell Division
Regulation Of Proteolysis
Mitotic Cell Cycle Process
Regulation Of Proteasomal Protein Catabolic Process
Mitotic Nuclear Division
Negative Regulation Of Protein Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Cell Cycle Checkpoint
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Mitotic Cell Cycle Process
Negative Regulation Of Transferase Activity
Regulation Of Mitotic Sister Chromatid Separation
Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
Protein Catabolic Process
Regulation Of Cell Division
Cell Division
Negative Regulation Of Cellular Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Cell Cycle Process
Spindle Assembly Checkpoint
Negative Regulation Of Cell Division
Regulation Of Chromosome Segregation
Mitotic Spindle Checkpoint
Positive Regulation Of Proteolysis
Protein Polyubiquitination
Negative Regulation Of Chromosome Segregation
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Regulation Of Mitotic Metaphase/anaphase Transition
Cellular Macromolecule Catabolic Process
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