FBXO5 and ANAPC1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		FBXO5	ANAPC1
Description		F-box protein 5	anaphase promoting complex subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Meiotic Spindle	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Anaphase-promoting Complex Binding Protein Kinase Binding Metal Ion Binding Molecular Function Inhibitor Activity Ubiquitin Ligase Inhibitor Activity	Molecular Adaptor Activity
	Biological Process	Oocyte Maturation Regulation Of DNA Replication DNA Damage Response Spindle Assembly Involved In Female Meiosis I Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle Organization Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Regulation Of Meiotic Nuclear Division Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Polymerization Spindle Assembly Cell Division Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Mesenchymal Stem Cell Migration Negative Regulation Of Cellular Senescence	Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Prostate cancer ( 23535732)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 23817571) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Corneal endothelial cell density ( 30894546) Corneal hysteresis ( 32716492 31246245 30894546) Corneal resistance factor ( 32716492 31246245 30894546) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Intraocular pressure ( 30054594 29785010) Obesity-related traits ( 23251661)
Interacting Genes		11 interacting genes: ANAPC1 ANAPC11 ANAPC7 CDC20 CDK1 EVI5 FZR1 RAD51 SKP1 SRC TPM3	12 interacting genes: CDC20 CDC27 FBXO5 FZR1 HRAS ID2 MDC1 PTTG1 SUMO2 UBC UBE2S WBP2
Entrez ID		26271	64682
HPRD ID		09348	09769
Ensembl ID		ENSG00000112029	ENSG00000153107
Uniprot IDs		Q9UKT4	Q9H1A4
PDB IDs		2M6N 4UI9 9GAW	4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 5LGG 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Meiotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Proteasomal Protein Catabolic Process Post-translational Protein Modification Protein K11-linked Ubiquitination Regulation Of Chromosome Segregation Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin Ligase Activator Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Reproductive Process Regulation Of Organelle Organization Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Branched Polyubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein K48-linked Ubiquitination Protein Polyubiquitination Positive Regulation Of Cell Cycle Phase Transition Protein Modification Process Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Modification By Small Protein Conjugation Proteolysis Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cytosol Positive Regulation Of Mitotic Nuclear Division Thymidine Biosynthetic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Thymidine Metabolic Process Cytoskeleton Positive Regulation Of Organelle Organization	Anaphase-promoting Complex Binding Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Cell Cycle Cell Division Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Meiotic Nuclear Division Regulation Of Cell Cycle Protein Modification Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Regulation Of Cell Cycle Process Regulation Of Reproductive Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Ubiquitin-protein Transferase Activator Activity Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Ligase Activator Activity Negative Regulation Of Cell Cycle Process Protein Polyubiquitination Protein Tag Activity Regulation Of Sister Chromatid Segregation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Positive Regulation Of Post-translational Protein Modification Regulation Of Chromosome Segregation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Negative Regulation Of Cellular Senescence Mitotic Cell Cycle Phase Transition Nucleus
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