CNN1 and PLRG1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		CNN1	PLRG1
Description		calponin 1	pleiotropic regulator 1
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GO Annotations	Cellular Component	Cytoskeleton Focal Adhesion Actin Cytoskeleton	Prp19 Complex Fibrillar Center Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nuclear Speck Nuclear Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Actin Binding Protein Binding Calmodulin Binding Actin Filament Binding	Protein Binding
	Biological Process	Regulation Of Smooth Muscle Contraction Actin Filament Organization Actomyosin Structure Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein Localization To Nucleus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Developmental Lineage of Mammary Gland Myoepithelial Cells	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)	Fibrinogen ( 21757653) Fibrinogen levels ( 28107422 29403010)
Interacting Genes		15 interacting genes: ACTA1 ADRB2 CALM1 CCHCR1 COG6 DNMBP FYN MYO1A NCAPD2 PLRG1 PRKCE SYCE1 TFPT TPM3 TUBB	14 interacting genes: APP CDC5L CEBPA CNN1 HNRNPM MIR106B MIR205 MIR93 MIRLET7A2 MIRLET7E MIRLET7G MIRLET7I MX1 ZSCAN1
Entrez ID		1264	5356
HPRD ID		02884	16181
Ensembl ID		ENSG00000130176	ENSG00000171566
Uniprot IDs		B7Z7E1 P51911 Q53FP8 V9HWA5	O43660
PDB IDs		1WYP	4YVD 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7AAV 7ABF 7ABG 7ABI 7DH6 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Actin Filament Chromosome Organization Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Body Mitotic Chromosome Condensation Cellular Response To Prostaglandin E Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Prostaglandin Stimulus Regulation Of Metal Ion Transport Response To Prostaglandin E Mitotic Cell Cycle Protein-containing Complex Binding Regulation Of Calcium Ion Transmembrane Transport Cell Cycle Phase Transition Fc-gamma Receptor Signaling Pathway Condensed Chromosome Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Monoatomic Ion Transport Innate Immune Response-activating Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Chromosome Condensation Cell Division Muscle Contraction Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Activation Of Innate Immune Response Cytoplasm Sarcomere Cellular Response To Oxygen-containing Compound Positive Regulation Of Organelle Organization Modulation Of Chemical Synaptic Transmission Cell Cycle G2/M Phase Transition Regulation Of Calcium Ion Transport Fc Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Chromosome Organization Involved In Meiotic Cell Cycle Response To Amyloid-beta Beta2-adrenergic Receptor Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Glycine Ethanol Binding Regulation Of Chromosome Organization Muscle System Process	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Extracellular Vesicle Positive Regulation Of Catabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Metabolic Process Extracellular Space RNA Destabilization MRNA Destabilization Regulation Of Gene Expression Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Interleukin-8 Production Negative Regulation Of Cell Population Proliferation Positive Regulation Of MRNA Metabolic Process Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction Regulation Of Translation Regulation Of Inflammatory Response Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Vascular Endothelial Growth Factor Production Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Amyloid-beta Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Response To Amyloid-beta Negative Regulation Of Osteoblast Differentiation
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