POLR2L and CCN3

Number of citations of the paper that reports this interaction (PubMedID 10474687)
22

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLR2L	CCN3
Description		RNA polymerase II, I and III subunit L	cellular communication network factor 3
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol	Extracellular Region Extracellular Space Cytoplasm Cytosol Gap Junction Extracellular Matrix Anchoring Junction
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Signaling Receptor Binding Notch Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Heparin Binding
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase I Transcription By RNA Polymerase I Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Ossification Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs			Insulin human
Diseases
GWAS		Pulse pressure ( 30578418)
Interacting Genes		27 interacting genes: AGR2 BANP CCDC85B CCN3 CHEK2 COIL EXOSC5 FAM217B L3MBTL3 NACC1 NFKBIB PHC2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2H PSMA6 REL RPAP1 SNX7 SPAG5 THAP1 TP53BP2 TRIP13 ZBTB14	31 interacting genes: ADSL ANKRD11 APOL6 C11orf87 CCN2 CDKN1A COL8A1 DLL1 FAM90A1 FBLN1 FN1 FRS3 FXR1 FXR2 GJA1 HOXA1 IGF1 IGF2 INS ITGAV KRTAP5-6 LCE1A LCE3D NID2 NOTCH1 POLR2L POU4F2 RECK S100A4 TNIP3 ZNF330
Entrez ID		5441	4856
HPRD ID		01155	01291
Ensembl ID		ENSG00000177700	ENSG00000136999
Uniprot IDs		P62875	P48745
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7LBM 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9EHZ 9EI1 9EI3 9EI4 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-templated Transcription DNA-directed RNA Polymerase Activity Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Nucleoplasm RNA Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA Binding Nucleus Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process 5'-3' RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process RNA Polymerase I Complex RNA Polymerase III Complex Nucleotidyltransferase Activity Positive Regulation Of Organelle Assembly Nucleolus Positive Regulation Of Autophagosome Assembly Positive Regulation Of Vacuole Organization NF-kappaB Binding Identical Protein Binding Purine Ribonucleoside Triphosphate Binding	Tissue Development Epidermis Development Integrin Binding Positive Regulation Of Growth Positive Regulation Of Developmental Growth Regulation Of Growth Regulation Of Developmental Growth Regulation Of Cell Differentiation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Fibroblast Proliferation Receptor Ligand Activity Insulin-like Growth Factor Receptor Binding Positive Regulation Of Glycogen Biosynthetic Process Wound Healing Positive Regulation Of Signal Transduction Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Cell Development Regulation Of Nervous System Development Insulin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Negative Regulation Of Gene Expression Angiogenesis Positive Regulation Of Cell Differentiation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Positive Regulation Of Intracellular Signal Transduction Regulation Of Fibroblast Proliferation Regulation Of Glycogen Biosynthetic Process Basement Membrane Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Response To Wounding Extracellular Region Positive Regulation Of Cell Communication Positive Regulation Of Signaling Integrin-mediated Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Endodermal Cell Differentiation Positive Regulation Of D-glucose Import Cell-matrix Adhesion Regulation Of Neurogenesis Regulation Of Glycogen Metabolic Process Regulation Of Somitogenesis Positive Regulation Of Neurogenesis Regulation Of Skeletal Muscle Tissue Growth
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