CKAP5 and PTPRN2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		CKAP5	PTPRN2
Description		cytoskeleton associated protein 5	protein tyrosine phosphatase receptor type N2
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Mitotic Spindle	Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Receptor Complex Synapse Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus-end Binding Microtubule Plus End Polymerase	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Hydrolase Activity
	Biological Process	Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein-containing Complex Organization Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation	Protein Dephosphorylation Lipid Metabolic Process Neurotransmitter Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Secretion
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Neutrophil degranulation
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748)	Bipolar disorder and schizophrenia ( 21057379) Breast cancer in childhood cancer survivors ( 29059430) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Calcium levels ( 25972035) Carotid plaque burden ( 28282560) Chronic rhinosinusitis ( 33393196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 27841878) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Hearing loss in noise exposure ( 33242228) Inflammatory skin disease ( 25574825) Intelligence (MTAG) ( 29326435) Myopia (pathological) ( 23049088) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Plasma anti-thyroid peroxidase levels ( 29678681) Refractive error ( 32231278) Response to amphetamines ( 22952603) Retinal detachment or retinal break ( 31816047) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Triacylglyceride levels ( 31551469)
Interacting Genes		16 interacting genes: ARHGEF16 AURKA CACNA1A CEBPA CLASP1 CLK1 DYRK1A HSPA13 NDC80 OLIG2 PTPRN2 SLAIN2 SUMO2 TOP1 TTC3 USP19	3 interacting genes: CKAP5 SPTBN4 UBQLN4
Entrez ID		9793	5799
HPRD ID		10830	03413
Ensembl ID		ENSG00000175216	ENSG00000155093
Uniprot IDs		Q14008	E7EM83 I6L9F8 Q92932
PDB IDs		4QMI 4QMJ	2QEP 4HTI 4HTJ
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine/tyrosine Kinase Activity Spindle Assembly Involved In Female Meiosis I Animal Organ Regeneration Regulation Of Proteasomal Protein Catabolic Process Regulation Of Microtubule Polymerization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process HMG Box Domain Binding Regulation Of Microtubule-based Process Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Meiotic Spindle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regeneration Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Plus-end Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Microtubule Nucleation Protein Serine/threonine Kinase Activity Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Cell Cycle Phase Transition Kinetochore Positive Regulation Of Microtubule Polymerization Regulation Of Organelle Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Peptidyl-serine Phosphorylation Spindle Microtubule Microtubule Cytoskeleton Organization Cell Division Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Positive Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process Histone H3T45 Kinase Activity Kinetochore Adaptor Activity Centrosomal Corona Regulation Of Cytoskeleton Organization Establishment Of Spindle Localization	Negative Regulation Of Autophagy Microtubule Plus End Polymerase Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Regulation Of Macroautophagy Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytoskeletal Protein-membrane Anchor Activity Regulation Of Organelle Organization Cytosolic Proteasome Complex Clustering Of Voltage-gated Sodium Channels Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Microtubule Nucleation Axon Hillock Cell Body Fiber Paranode Region Of Axon Spectrin Negative Regulation Of Catabolic Process Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization K48-linked Polyubiquitin Modification-dependent Protein Binding Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Negative Regulation Of Heart Rate Regulation Of Protein-containing Complex Assembly Regulation Of Autophagosome Maturation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Microtubule Nucleation Centrosome Duplication Microtubule Polymerization Microtubule Plus-end Binding Microtubule Depolymerization Node Of Ranvier Ankyrin Binding Negative Regulation Of Heart Contraction Microtubule Plus-end Regulation Of Cytoskeleton Organization Transmission Of Nerve Impulse Negative Regulation Of Blood Circulation Axon Initial Segment
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