CKAP5 and PTPRN2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		CKAP5	PTPRN2
Gene Name		cytoskeleton associated protein 5	protein tyrosine phosphatase, receptor type, N polypeptide 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Gamma-tubulin Complex Centrosome Cytosol Microtubule Cytoskeleton Membrane Microtubule Plus-end Protein Complex	Endoplasmic Reticulum Lumen Integral Component Of Plasma Membrane Secretory Granule Transport Vesicle Membrane Terminal Bouton Receptor Complex
	Molecular Function	Protein Binding	Transmembrane Receptor Protein Tyrosine Phosphatase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Spindle Organization Mitotic Nuclear Division Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity RNA Transport Centrosome Organization Cell Division	Protein Dephosphorylation Negative Regulation Of GTPase Activity Peptidyl-tyrosine Dephosphorylation
Pathways		Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)	Bipolar disorder and schizophrenia ( 21057379) Myopia (pathological) ( 23049088) Obesity-related traits ( 23251661) Response to amphetamines ( 22952603)
Protein-Protein Interactions		6 interactors: AURKA CACNA1A PTPRN2 TACC1 TOP1 USP19	3 interactors: CKAP5 SPTBN4 UBQLN4
Entrez ID		9793	5799
HPRD ID		10830	03413
Ensembl ID		ENSG00000175216	ENSG00000155093
Uniprot IDs		Q14008	Q92932
PDB IDs			2QEP 4HTI 4HTJ
Enriched GO Terms of Interacting Partners?		Cell Division Negative Regulation Of Spindle Checkpoint Cerebellar Molecular Layer Development Vestibular Nucleus Development Spindle Assembly Involved In Female Meiosis I Regulation Of Protein Stability Cell Growth Spindle Assembly Involved In Meiosis Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of Microtubule-based Process Gamma-aminobutyric Acid Secretion Spindle Stabilization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Hypoxia Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Cell Cycle Process Rhythmic Synaptic Transmission Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Oocyte Maturation Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Meiotic Spindle Organization Positive Regulation Of Cell Cycle Protein Localization To Centrosome Mitotic Centrosome Separation Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Female Meiosis I Positive Regulation Of Oocyte Development Centrosome Separation Negative Regulation Of Hormone Biosynthetic Process Pons Development Embryonic Cleavage Regulation Of Protein Catabolic Process Cerebellar Purkinje Cell Differentiation Interkinetic Nuclear Migration Organelle Localization Cerebellar Purkinje Cell Layer Morphogenesis Protein Localization To Cytoskeleton Histone-serine Phosphorylation Microtubule Cytoskeleton Organization Regulation Of Spindle Checkpoint Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Skeletal Muscle Tissue Development Reflex Behavioral Response To Pain Neurogenesis Regulation Of Cell Cycle Process	Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Heart Rate Cytoskeletal Anchoring At Plasma Membrane Neuronal Ion Channel Clustering
Tagcloud ?		abscission binucleated bridges centrosome chfr coil coiled converges cytokinetic division envelope epistatically explanations fam161b interactome interactors localize lymphangioleiomyomatosis players poles purify ser939 tacc tacc3 tog tsc tsc1 tsc2 tuberous	aldh1 castration cd45 circulation ctcs elasticity emt esr2 foxp3 highlighting igf2 incremental individually invasiveness microfiltration microfluidics micromanipulator noncancerous personalized postulate prognostication retrieved shed signatures smoothness stream tgfb3 transitioning wnt5a
Tagcloud (Difference) ?		abscission binucleated bridges centrosome chfr coil coiled converges cytokinetic division envelope epistatically explanations fam161b interactome interactors localize lymphangioleiomyomatosis players poles purify ser939 tacc tacc3 tog tsc tsc1 tsc2 tuberous	aldh1 castration cd45 circulation ctcs elasticity emt esr2 foxp3 highlighting igf2 incremental individually invasiveness microfiltration microfluidics micromanipulator noncancerous personalized postulate prognostication retrieved shed signatures smoothness stream tgfb3 transitioning wnt5a
Tagcloud (Intersection) ?