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RCVRN and TOP1
Number of citations of the paper that reports this interaction (PubMedID
12549820
)
0
Data Source:
BioGRID
(unspecified method)
RCVRN
TOP1
Description
recoverin
DNA topoisomerase I
Image
GO Annotations
Cellular Component
Photoreceptor Outer Segment
Photoreceptor Inner Segment
Membrane
Dendrite
Cell Projection
Perikaryon
Nuclear Chromosome
P-body
Fibrillar Center
Dense Fibrillar Component
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Protein-DNA Complex
Perikaryon
Molecular Function
Calcium Ion Binding
Calcium Sensitive Guanylate Cyclase Activator Activity
Metal Ion Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
RNA Binding
DNA Topoisomerase Activity
DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
DNA Binding, Bending
Isomerase Activity
Protein Domain Specific Binding
Chromatin DNA Binding
Protein-containing Complex Binding
Supercoiled DNA Binding
Biological Process
Signal Transduction
Visual Perception
Phototransduction
Regulation Of Signal Transduction
Regulation Of Calcium Ion Transport
DNA Replication
DNA Topological Change
Chromatin Remodeling
Chromosome Segregation
Circadian Rhythm
Response To Temperature Stimulus
RRNA Transcription
Response To Xenobiotic Stimulus
Response To Gamma Radiation
Programmed Cell Death
Peptidyl-serine Phosphorylation
Animal Organ Regeneration
Circadian Regulation Of Gene Expression
Embryonic Cleavage
Rhythmic Process
Response To CAMP
Cellular Response To Luteinizing Hormone Stimulus
Pathways
Inactivation, recovery and regulation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
SUMOylation of DNA replication proteins
Drugs
Myristic acid
Irinotecan
Dactinomycin
Doxorubicin
Topotecan
Camptothecin
Edotecarin
Lucanthone
Elsamitrucin
7-ethyl-10-hydroxycamptothecin
Sodium stibogluconate
Cositecan
XMT-1001
Rubitecan
2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Hexylresorcinol
Sacituzumab govitecan
Trastuzumab deruxtecan
Diseases
GWAS
Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) (
28560309
)
Antipsychotic drug-induced weight gain in schizophrenia (
31447353
)
Brain morphology (MOSTest) (
32665545
)
Cholesterol, total (
24097068
20686565
)
Hemoglobin (
32888494
)
Hip circumference adjusted for BMI (
34021172
)
LDL cholesterol (
20686565
24097068
)
LDL cholesterol levels (
28334899
)
LDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
LDL cholesterol levels x short total sleep time interaction (2df test) (
31719535
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Male-pattern baldness (
28196072
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Total cholesterol levels (
28334899
)
Urate levels (
31578528
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
11 interacting genes:
CAV1
GIT2
GRK1
GRK2
GRK5
GRK6
IL15RA
PQBP1
SMAD3
TGFBR2
TOP1
59 interacting genes:
APAF1
APP
ATM
BARD1
BRCA1
BRD2
BTBD1
BTBD2
BUB3
CASP3
CASP6
CDK8
CEBPA
CKAP5
CSNK2A1
CSNK2A2
DDB2
ELK3
ERCC8
ERG
FSHR
GEMIN4
IL7R
IRF4
IRF8
IRF9
JAK1
JUN
LIG4
LSM4
MDM2
NCL
NCOA6
PDE10A
PIAS4
PPP2R2B
PRB1
PYGM
RBL1
RBL2
RCVRN
SF3B1
SFPQ
SNW1
SRPK2
SRSF1
SRSF11
SUMO1
SYMPK
TARBP2
TDP1
TIAM1
TOPORS
TP53
TRIM32
TUBD1
U2AF2
UBE2I
XRCC5
Entrez ID
5957
7150
HPRD ID
01558
00535
Ensembl ID
ENSG00000109047
ENSG00000198900
Uniprot IDs
P35243
P11387
Q9BVT2
PDB IDs
2D8N
1A31
1A35
1A36
1EJ9
1K4S
1K4T
1LPQ
1NH3
1R49
1RR8
1RRJ
1SC7
1SEU
1T8I
1TL8
Enriched GO Terms of Interacting Partners
?
G Protein-coupled Receptor Kinase Activity
Beta-adrenergic Receptor Kinase Activity
Regulation Of G Protein-coupled Receptor Signaling Pathway
Protein Serine/threonine Kinase Activity
Gastrulation
Regulation Of The Force Of Heart Contraction By Chemical Signal
Tachykinin Receptor Signaling Pathway
Protein Kinase Activity
Animal Organ Development
Regulation Of Signal Transduction
Kinase Activity
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Double-stranded DNA Binding
G Protein-coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
SMAD Protein Signal Transduction
Release Of Cytochrome C From Mitochondria
RRNA Transcription
Regulation Of The Force Of Heart Contraction
ATP Binding
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
Negative Regulation Of Fibroblast Proliferation
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Death
Programmed Cell Death
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Programmed Necrotic Cell Death
Signal Transduction
Fibroblast Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of Relaxation Of Smooth Muscle
Regulation Of Muscle System Process
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
Inward Rectifier Potassium Channel Inhibitor Activity
Leukocyte Activation
Somitogenesis
Segmentation
Negative Regulation Of Lung Blood Pressure
In Utero Embryonic Development
Positive Regulation Of MiRNA Transcription
Chordate Embryonic Development
Nuclear Mineralocorticoid Receptor Binding
Transcription Coactivator Binding
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Positive Regulation Of Tolerance Induction To Self Antigen
Superior Endocardial Cushion Morphogenesis
Nucleoplasm
Nucleus
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Double-strand Break Repair
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Regulation Of RNA Metabolic Process
Macromolecule Metabolic Process
DNA Repair
Response To Ionizing Radiation
Response To Radiation
Nucleobase-containing Compound Metabolic Process
Response To Stress
Cellular Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Regulation Of Macromolecule Biosynthetic Process
Response To X-ray
Regulation Of Programmed Cell Death
Regulation Of Metabolic Process
Chromatin
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Enzyme Binding
MRNA Metabolic Process
Cellular Response To Radiation
Positive Regulation Of Neuron Apoptotic Process
Intrinsic Apoptotic Signaling Pathway
DNA Metabolic Process
DNA Topoisomerase Binding
Nuclear Speck
Cellular Developmental Process
Positive Regulation Of Apoptotic Process
Transcription Cis-regulatory Region Binding
Negative Regulation Of Cell Cycle
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein-RNA Complex Assembly
Protein Polyubiquitination
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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