TBPL1 and GTF2A2

Number of citations of the paper that reports this interaction (PubMedID 10570139)
38

Data Source:
HPRD (in vivo)

		TBPL1	GTF2A2
Description		TATA-box binding protein like 1	general transcription factor IIA subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Transcription Factor TFIIA Complex Cytoplasm	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity General Transcription Initiation Factor Activity	RNA Polymerase II General Transcription Initiation Factor Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Acrosome Assembly DTTP Biosynthetic Process DNA-templated Transcription Initiation Transcription By RNA Polymerase II Spermatogenesis Spermatid Nucleus Differentiation Nucleobase-containing Compound Biosynthetic Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways			HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Height ( 28552196) Night sleep phenotypes ( 27126917)	Macular thickness ( 30535121)
Interacting Genes		18 interacting genes: ABCF3 APP DVL3 FBXO7 GTF2A1 GTF2A2 GTF2B IRAK4 LSM5 NDUFA6 NF1 PLIN3 PRNP PTCD3 RAB35 RPL10 SLC35F6 TNNT1	9 interacting genes: GTF2A1 GTF2A1L GTF2E1 HSF1 PTPN11 TAF4 TBP TBPL1 TRIM7
Entrez ID		9519	2958
HPRD ID		09272	02747
Ensembl ID		ENSG00000028839	ENSG00000140307
Uniprot IDs		P62380	B2R506 P52657
PDB IDs			1NVP 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M4S 6MZM 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGI 7EGJ 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Synaptic Potentiation Cytosol TBP-class Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIIA Complex Transcription Factor TFIID Complex Protein Heterodimerization Activity RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II General Transcription Initiation Factor Binding Transcription Initiation At RNA Polymerase II Promoter Transcription Preinitiation Complex Assembly Positive Regulation Of Neuron Apoptotic Process Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Transcription Preinitiation Complex DNA-templated Transcription Initiation Regulation Of Neuron Apoptotic Process Intracellular Copper Ion Homeostasis Copper Ion Homeostasis RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cellular Response To Copper Ion Molecular Function Activator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Response To Copper Ion Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Frizzled Binding Cellular Response To Nerve Growth Factor Stimulus Protein-DNA Complex Assembly Transcriptional Start Site Selection At RNA Polymerase II Promoter Positive Regulation Of Mast Cell Apoptotic Process Type 8 Metabotropic Glutamate Receptor Binding Slow-twitch Skeletal Muscle Fiber Contraction Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Plasticity Cellular Response To Amyloid-beta Protein-containing Complex Assembly Regulation Of Amyloid Precursor Protein Catabolic Process	Transcription Factor TFIIA Complex DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Transcription Initiation At RNA Polymerase II Promoter Transcription Factor TFIID Complex Transcription By RNA Polymerase II Male Germ Cell Nucleus DNA-templated Transcription RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II General Transcription Initiation Factor Binding Pronucleus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Aryl Hydrocarbon Receptor Binding Nucleic Acid Metabolic Process Regulation Of DNA-templated Transcription Initiation Macromolecule Metabolic Process Macromolecule Biosynthetic Process Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus DNA Binding MRNA Transcription By RNA Polymerase II Protein-containing Complex Euchromatin MRNA Transcription Cellular Response To Nitroglycerin Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Positive Regulation Of Macromolecule Biosynthetic Process Protein Heterodimerization Activity Developmental Process Involved In Reproduction Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription Factor TFIIE Complex Response To Nitroglycerin Sequence-specific Single Stranded DNA Binding Cellular Response To Diamide Intestinal Epithelial Cell Migration General Transcription Initiation Factor Activity Positive Regulation Of RNA Metabolic Process Translation Elongation Factor Binding
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