TBPL1 and IRAK4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		TBPL1	IRAK4
Description		TATA-box binding protein like 1	interleukin 1 receptor associated kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Transcription Factor TFIIA Complex Cytoplasm	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Endosome Membrane Extrinsic Component Of Plasma Membrane
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity General Transcription Initiation Factor Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Acrosome Assembly DTTP Biosynthetic Process DNA-templated Transcription Initiation Transcription By RNA Polymerase II Spermatogenesis Spermatid Nucleus Differentiation Nucleobase-containing Compound Biosynthetic Process	Toll-like Receptor Signaling Pathway Immune System Process Neutrophil Mediated Immunity MyD88-dependent Toll-like Receptor Signaling Pathway Signal Transduction JNK Cascade Toll Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Interleukin-1-mediated Signaling Pathway Neutrophil Migration
Pathways			PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs			1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE Fostamatinib
Diseases			Defects of toll-like receptor signaling, including the following disease: Il-1 receptor-associated kinase 4 (IRAK-4) deficiency
GWAS		Height ( 28552196) Night sleep phenotypes ( 27126917)	Immune reponse to smallpox (secreted TNF-alpha) ( 22610502) Inflammatory bowel disease ( 27569725)
Interacting Genes		18 interacting genes: ABCF3 APP DVL3 FBXO7 GTF2A1 GTF2A2 GTF2B IRAK4 LSM5 NDUFA6 NF1 PLIN3 PRNP PTCD3 RAB35 RPL10 SLC35F6 TNNT1	22 interacting genes: ARNT EIF4EBP1 H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 IKBKG IL36RN IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6 TRIM7 ZNF597
Entrez ID		9519	51135
HPRD ID		09272	06051
Ensembl ID		ENSG00000028839	ENSG00000198001
Uniprot IDs		P62380	B2RAP9 B4E359 Q69FE3 Q9NWZ3
PDB IDs			2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP 4RMZ 4U97 4U9A 4XS2 4Y73 4YO6 4YP8 4ZTL 4ZTM 4ZTN 5K72 5K75 5K76 5K7G 5K7I 5KX7 5KX8 5T1S 5T1T 5UIQ 5UIR 5UIS 5UIT 5UIU 5W84 5W85 6EG9 6EGA 6EGD 6EGE 6EGF 6F3D 6F3E 6F3G 6F3I 6LXY 6MOM 6N8G 6O8U 6O94 6O95 6O9D 6RFI 6RFJ 6THW 6THX 6THZ 6TI8 6TIA 6UYA 6VQL 7C2V 7C2W 7QG1 7QG2 7QG3 7QG5 8ATB 8ATL 8ATN 8BR5 8BR6 8BR7 8DKS 8SCE 8SCV 8SCW 8TVM 8TVN 8TX0 8UCB 8UCC 8V1O 8V2F 8V2L 8W3W 8W3X 8WTF
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Synaptic Potentiation Cytosol TBP-class Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIIA Complex Transcription Factor TFIID Complex Protein Heterodimerization Activity RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II General Transcription Initiation Factor Binding Transcription Initiation At RNA Polymerase II Promoter Transcription Preinitiation Complex Assembly Positive Regulation Of Neuron Apoptotic Process Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Transcription Preinitiation Complex DNA-templated Transcription Initiation Regulation Of Neuron Apoptotic Process Intracellular Copper Ion Homeostasis Copper Ion Homeostasis RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cellular Response To Copper Ion Molecular Function Activator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Response To Copper Ion Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Frizzled Binding Cellular Response To Nerve Growth Factor Stimulus Protein-DNA Complex Assembly Transcriptional Start Site Selection At RNA Polymerase II Promoter Positive Regulation Of Mast Cell Apoptotic Process Type 8 Metabotropic Glutamate Receptor Binding Slow-twitch Skeletal Muscle Fiber Contraction Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Plasticity Cellular Response To Amyloid-beta Protein-containing Complex Assembly Regulation Of Amyloid Precursor Protein Catabolic Process	Chromosome Condensation Nucleosomal DNA Binding Negative Regulation Of DNA Recombination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA Recombination Chromatin DNA Binding Structural Constituent Of Chromatin Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleosome Assembly Cell Surface Pattern Recognition Receptor Signaling Pathway Nucleosome Euchromatin Nucleosome Organization Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Toll Signaling Pathway Signaling Adaptor Activity Regulation Of Macromolecule Metabolic Process Innate Immune Response Response To Lipopolysaccharide Interleukin-33-mediated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Protein-DNA Complex Assembly Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Production Defense Response To Symbiont Defense Response To Other Organism Regulation Of Metabolic Process Regulation Of Cytokine Production Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Immune Response Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Chemokine Production Regulation Of DNA Metabolic Process Response To External Biotic Stimulus
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