TBPL1 and GTF2A1

Number of citations of the paper that reports this interaction (PubMedID 10570139)
38

Data Source:
HPRD (in vivo)

		TBPL1	GTF2A1
Description		TATA-box binding protein like 1	general transcription factor IIA subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Transcription Factor TFIIA Complex Cytoplasm	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytoplasm Cytosol Transcription Preinitiation Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity General Transcription Initiation Factor Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Acrosome Assembly DTTP Biosynthetic Process DNA-templated Transcription Initiation Transcription By RNA Polymerase II Spermatogenesis Spermatid Nucleus Differentiation Nucleobase-containing Compound Biosynthetic Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways			HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Height ( 28552196) Night sleep phenotypes ( 27126917)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Neutrophil count ( 32888494) Night sleep phenotypes ( 27126917) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: ABCF3 APP DVL3 FBXO7 GTF2A1 GTF2A2 GTF2B IRAK4 LSM5 NDUFA6 NF1 PLIN3 PRNP PTCD3 RAB35 RPL10 SLC35F6 TNNT1	26 interacting genes: BCL3 BIRC7 CREB1 CSNK2A1 CSNK2A2 GTF2A2 GTF2E1 GTF2E2 GTF2F1 HMGB1 NCOA6 NFYA PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 SP4 TAF1 TAF4 TAF4B TASP1 TBP TBPL1 TRIP4
Entrez ID		9519	2957
HPRD ID		09272	02748
Ensembl ID		ENSG00000028839	ENSG00000165417
Uniprot IDs		P62380	P52655
PDB IDs			1NVP 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M4S 6MZM 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGI 7EGJ 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Synaptic Potentiation Cytosol TBP-class Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIIA Complex Transcription Factor TFIID Complex Protein Heterodimerization Activity RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II General Transcription Initiation Factor Binding Transcription Initiation At RNA Polymerase II Promoter Transcription Preinitiation Complex Assembly Positive Regulation Of Neuron Apoptotic Process Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Transcription Preinitiation Complex DNA-templated Transcription Initiation Regulation Of Neuron Apoptotic Process Intracellular Copper Ion Homeostasis Copper Ion Homeostasis RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cellular Response To Copper Ion Molecular Function Activator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Response To Copper Ion Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Frizzled Binding Cellular Response To Nerve Growth Factor Stimulus Protein-DNA Complex Assembly Transcriptional Start Site Selection At RNA Polymerase II Promoter Positive Regulation Of Mast Cell Apoptotic Process Type 8 Metabotropic Glutamate Receptor Binding Slow-twitch Skeletal Muscle Fiber Contraction Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Plasticity Cellular Response To Amyloid-beta Protein-containing Complex Assembly Regulation Of Amyloid Precursor Protein Catabolic Process	RNA Polymerase II General Transcription Initiation Factor Activity DNA-templated Transcription Initiation Transcription Factor TFIID Complex Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation DNA-templated Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Binding RNA Metabolic Process Nucleic Acid Metabolic Process Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II-specific DNA-binding Transcription Factor Binding MRNA Transcription Transcription Factor TFIIA Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Factor TFIIE Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Protein Kinase CK2 Complex Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Nucleus Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Binding Male Germ Cell Nucleus Regulation Of Gene Expression
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