HMGXB4 and LENG8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HMGXB4	LENG8
Description		HMG-box containing 4	leukocyte receptor cluster member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus NURF Complex	Nucleus Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Endosome To Lysosome Transport Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Platelet count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		24 interacting genes: AKAP17A CREBBP EPM2A H3-4 HABP4 INO80B JMJD6 LENG8 MX1 NKAPD1 NR1H2 PIAS2 SRPK2 STAC3 STRBP SUMO2 TENT5B TNNT1 TSC22D1 TSPYL2 UBE2I UBL5 UROD ZCCHC10	49 interacting genes: ANKHD1 ARID5A ATN1 BAG3 C10orf55 CAMK2A CEP70 CFAP53 CIMIP2B COG2 CPSF7 CYSRT1 DMRTB1 DVL3 GSE1 HMGXB4 HNRNPM IKBKG INCA1 INTS11 KDM1A LASP1 MAGED1 MAPK1IP1L MIA3 MSX2 MYOZ3 NCBP3 NUTM2F PCID2 PER2 PRDM16 PRMT5 PRMT6 PYGO1 RHOXF2 SMARCB1 SMN1 SMYD1 SNRPA SOCS7 SUV39H1 TFG TLE5 TNIP1 TRAF4 TSG101 VGLL3 ZNF34
Entrez ID		10042	114823
HPRD ID		05267	11226
Ensembl ID		ENSG00000100281	ENSG00000167615
Uniprot IDs		Q7Z641 Q9UGU5	A0A087WUE4 C9JMY0 Q96PV6
PDB IDs
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Protein Sumoylation Protein Tag Activity Regulation Of RNA Splicing RNA Splicing MRNA Metabolic Process Nuclear Body Organization Nucleus Chromatin Remodeling Nucleic Acid Metabolic Process PML Body MRNA Processing Voltage-gated Calcium Channel Complex Nucleoplasm Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Binding Presynaptic Cytosol Postsynaptic Cytosol RNA Metabolic Process Slow-twitch Skeletal Muscle Fiber Contraction Skeletal Muscle Contraction SUMO Conjugating Enzyme Activity Positive Regulation Of Secretion Of Lysosomal Enzymes Uroporphyrinogen Decarboxylase Activity Carbohydrate Phosphatase Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Chromatin Organization	Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Histone H3 Methyltransferase Activity Transcription Corepressor Activity Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Histone Arginine N-methyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Histone H4R3 Methyltransferase Activity Chromatin Remodeling Protein Binding Negative Regulation Of RNA Metabolic Process Chromatin Organization Methyltransferase Activity Regulation Of Gene Expression Histone Methyltransferase Activity Transcription Coactivator Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Histone H3K9me2 Methyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Methylation Protein-arginine N-methyltransferase Activity Histone H3K9 Methyltransferase Activity Regulation Of Metabolic Process Nucleoplasm Circadian Rhythm Negative Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Circadian Regulation Of Gene Expression P53 Binding Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Developmental Process DNA-templated Transcription Termination
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