HMGXB4 and EPM2A

Number of citations of the paper that reports this interaction (PubMedID 26493215)
30

Data Source:
BioGRID (two hybrid)

		HMGXB4	EPM2A
Description		HMG-box containing 4	EPM2A glucan phosphatase, laforin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus NURF Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Perikaryon Cytoplasmic Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding	Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Carbohydrate Phosphatase Activity Carbohydrate Binding Polysaccharide Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Glycogen Binding Starch Binding
	Biological Process	Endosome To Lysosome Transport Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway	Autophagosome Assembly Regulation Of Cell Growth Glycogen Metabolic Process Glycogen Biosynthetic Process Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Calcium Ion Transport Autophagy Mitochondrion Organization Nervous System Development Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Phosphatase Activity Glial Cell Proliferation L-glutamate Transmembrane Transport Wnt Signaling Pathway Positive Regulation Of Macroautophagy Dephosphorylation Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Negative Regulation Of Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Carbohydrate Phosphorylation Habituation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane
Pathways			Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Platelet count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)
Interacting Genes		24 interacting genes: AKAP17A CREBBP EPM2A H3-4 HABP4 INO80B JMJD6 LENG8 MX1 NKAPD1 NR1H2 PIAS2 SRPK2 STAC3 STRBP SUMO2 TENT5B TNNT1 TSC22D1 TSPYL2 UBE2I UBL5 UROD ZCCHC10	15 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS
Entrez ID		10042	7957
HPRD ID		05267	06345
Ensembl ID		ENSG00000100281	ENSG00000112425
Uniprot IDs		Q7Z641 Q9UGU5	O95278
PDB IDs			4R30 4RKK
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Protein Sumoylation Protein Tag Activity Regulation Of RNA Splicing RNA Splicing MRNA Metabolic Process Nuclear Body Organization Nucleus Chromatin Remodeling Nucleic Acid Metabolic Process PML Body MRNA Processing Voltage-gated Calcium Channel Complex Nucleoplasm Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Binding Presynaptic Cytosol Postsynaptic Cytosol RNA Metabolic Process Slow-twitch Skeletal Muscle Fiber Contraction Skeletal Muscle Contraction SUMO Conjugating Enzyme Activity Positive Regulation Of Secretion Of Lysosomal Enzymes Uroporphyrinogen Decarboxylase Activity Carbohydrate Phosphatase Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Chromatin Organization	AMP-activated Protein Kinase Activity Regulation Of Generation Of Precursor Metabolites And Energy Nucleotide-activated Protein Kinase Complex Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Glycogen Biosynthetic Process Protein Localization To Lipid Droplet Generation Of Precursor Metabolites And Energy Regulation Of Glycogen Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Carbohydrate Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glycogen Metabolic Process Regulation Of Carbohydrate Catabolic Process Glycogen Binding Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Phosphatase Type 1 Complex Fatty Acid Homeostasis Hepatocyte Apoptotic Process Glycogen Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Response To Hormone Fatty Acid Biosynthetic Process Response To Glucose Chromatin Remodeling Polysaccharide Biosynthetic Process Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Protein Phosphatase 1 Binding Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Response To Monosaccharide Protein K6-linked Ubiquitination Response To Prostaglandin E Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Positive Regulation Of Translation Positive Regulation Of Small Molecule Metabolic Process Response To Carbohydrate Macromolecule Metabolic Process Nuclear Speck Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process
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