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HMGXB4 and UROD
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
HMGXB4
UROD
Gene Name
HMG box domain containing 4
uroporphyrinogen decarboxylase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
NURF Complex
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
DNA Binding
Chromatin Binding
Uroporphyrinogen Decarboxylase Activity
Biological Process
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Endosome To Lysosome Transport
Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Porphyrin-containing Compound Metabolic Process
Protoporphyrinogen IX Biosynthetic Process
Heme Biosynthetic Process
Small Molecule Metabolic Process
Pathways
Heme biosynthesis
Metabolism of porphyrins
Drugs
Coproporphyrin I
Coproporphyrin Iii
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
HABP4
HIST3H3
JMJD6
NR1H2
TNNT1
TSC22D1
UROD
6 interactors:
CHD3
EGFR
FAF1
FAM84B
HMGXB4
VIM
Entrez ID
10042
7389
HPRD ID
05267
01441
Ensembl ID
ENSG00000100281
ENSG00000126088
Uniprot IDs
Q7Z641
Q9UGU5
P06132
PDB IDs
1JPH
1JPI
1JPK
1R3Q
1R3R
1R3S
1R3T
1R3V
1R3W
1R3Y
1URO
2Q6Z
2Q71
3GVQ
3GVR
3GVV
3GVW
3GW0
3GW3
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Secretion Of Lysosomal Enzymes
Positive Regulation Of Pancreatic Juice Secretion
Positive Regulation Of High-density Lipoprotein Particle Assembly
Histone H3-R2 Demethylation
Histone H4-R3 Demethylation
Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of High-density Lipoprotein Particle Assembly
Nitrogen Compound Metabolic Process
Negative Regulation Of Pinocytosis
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Slow-twitch Skeletal Muscle Fiber Contraction
Negative Regulation Of Cholesterol Storage
Recognition Of Apoptotic Cell
Transcription, DNA-templated
Positive Regulation Of Digestive System Process
Protoporphyrinogen IX Biosynthetic Process
RNA Biosynthetic Process
Protoporphyrinogen IX Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Cholesterol Homeostasis
Positive Regulation Of Lipoprotein Lipase Activity
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Transport
Phagocytosis, Recognition
Biosynthetic Process
Homeostatic Process
Negative Regulation Of Lipid Storage
Regulation Of Triglyceride Biosynthetic Process
Regulation Of Cholesterol Efflux
Regulation Of Interferon-gamma-mediated Signaling Pathway
Negative Regulation Of Muscle Contraction
Regulation Of Response To Interferon-gamma
Negative Regulation Of Lipid Transport
Retinoic Acid Receptor Signaling Pathway
RNA Metabolic Process
Skeletal Muscle Contraction
Heme Biosynthetic Process
Protein Hydroxylation
Macrophage Activation
Positive Regulation Of Lipid Storage
Actin-myosin Filament Sliding
Positive Regulation Of Fatty Acid Metabolic Process
Apoptotic Cell Clearance
Muscle Filament Sliding
Astrocyte Development
Astrocyte Differentiation
Glial Cell Development
Alkanesulfonate Metabolic Process
Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling
Astrocyte Activation
Regulation Of Protein Import Into Nucleus
Glial Cell Differentiation
Regulation Of Protein Localization To Nucleus
Regulation Of Nucleocytoplasmic Transport
Activation Of Phospholipase A2 Activity
Negative Regulation Of Signal Transduction
Positive Regulation Of Phospholipase A2 Activity
Gliogenesis
Negative Regulation Of Signaling
Response To Cobalamin
Response To UV-A
Regulation Of Intracellular Protein Transport
Cytoplasmic Sequestering Of NF-kappaB
Response To Hydroxyisoflavone
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
Bergmann Glial Cell Differentiation
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Catenin Import Into Nucleus
Regulation Of Phospholipase A2 Activity
Regulation Of Protein Catabolic Process
Regulation Of Superoxide Anion Generation
Magnesium Ion Homeostasis
Regulation Of Metabolic Process
Regulation Of Intracellular Transport
Intermediate Filament Organization
Negative Regulation Of NF-kappaB Import Into Nucleus
Cellular Response To Estradiol Stimulus
Lens Fiber Cell Development
Protein Insertion Into Membrane
Cytoplasmic Sequestering Of Transcription Factor
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Synaptic Transmission, Glutamatergic
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Catenin Import Into Nucleus
Cellular Response To Epidermal Growth Factor Stimulus
Cytoplasmic Sequestering Of Protein
Tagcloud
?
affinities
arg37
arg41
arg803
asp863
attempts
backbone
candidates
catalytic
cmu
computational
decarboxylase
edu
egfr
evolving
head
her2
http
modulate
neck
radiotherapy
residues
taiwan
tcm
thr854
thr862
traditional
tw
uroporphyrinogen
Tagcloud (Difference)
?
affinities
arg37
arg41
arg803
asp863
attempts
backbone
candidates
catalytic
cmu
computational
decarboxylase
edu
egfr
evolving
head
her2
http
modulate
neck
radiotherapy
residues
taiwan
tcm
thr854
thr862
traditional
tw
uroporphyrinogen
Tagcloud (Intersection)
?