HMGXB4 and NR1H2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HMGXB4	NR1H2
Gene Name		HMG box domain containing 4	nuclear receptor subfamily 1, group H, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	NURF Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific Transcription Regulatory Region DNA Binding RNA Polymerase II Transcription Factor Recruiting Transcription Factor Activity DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Apolipoprotein A-I Receptor Binding Retinoid X Receptor Binding ATPase Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription, DNA-templated Endosome To Lysosome Transport Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Regulation Of Cholesterol Homeostasis
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs			(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid Benzenesulfonyl N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
Diseases
GWAS
Protein-Protein Interactions		7 interactors: HABP4 HIST3H3 JMJD6 NR1H2 TNNT1 TSC22D1 UROD	46 interactors: BAG6 C14orf1 CDKN1A CHD3 COL4A5 CSAD DUSP12 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PRKCA RARA RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SRC SUV39H1 TMEM161A UBE2D1 UBE2I VDR VIM YY1 ZXDC
Entrez ID		10042	7376
HPRD ID		05267	02660
Ensembl ID		ENSG00000100281	ENSG00000131408
Uniprot IDs		Q7Z641 Q9UGU5	B4DNM6 F1D8P7 M0R2F9 P55055
PDB IDs			1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly Nitrogen Compound Metabolic Process Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Slow-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Cholesterol Storage Recognition Of Apoptotic Cell Transcription, DNA-templated Positive Regulation Of Digestive System Process Protoporphyrinogen IX Biosynthetic Process RNA Biosynthetic Process Protoporphyrinogen IX Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Homeostasis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Phagocytosis, Recognition Biosynthetic Process Homeostatic Process Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Muscle Contraction Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process Skeletal Muscle Contraction Heme Biosynthetic Process Protein Hydroxylation Macrophage Activation Positive Regulation Of Lipid Storage Actin-myosin Filament Sliding Positive Regulation Of Fatty Acid Metabolic Process Apoptotic Cell Clearance Muscle Filament Sliding	Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Organic Substance Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Reproductive Structure Development Reproductive System Development System Development Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Hormone Multicellular Organismal Development Cell Differentiation Single Organism Reproductive Process Anatomical Structure Development Developmental Process Involved In Reproduction Developmental Process Reproductive Process Cellular Response To Steroid Hormone Stimulus Signal Transduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cellular Response To Organic Substance Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Chromatin Organization Response To Stimulus Hormone-mediated Signaling Pathway Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Signaling
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