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HMGXB4 and NR1H2
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
HMGXB4
NR1H2
Description
HMG-box containing 4
nuclear receptor subfamily 1 group H member 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
NURF Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Molecular Function
DNA Binding
Protein Binding
Identical Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Chromatin DNA Binding
Apolipoprotein A-I Receptor Binding
Sequence-specific DNA Binding
Metal Ion Binding
Nuclear Retinoid X Receptor Binding
ATPase Binding
Biological Process
Endosome To Lysosome Transport
Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Hormone-mediated Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Positive Regulation Of Lipid Storage
Negative Regulation Of Cholesterol Storage
Cell Differentiation
Intracellular Receptor Signaling Pathway
Response To Nutrient Levels
Negative Regulation Of Lipid Transport
Positive Regulation Of Cholesterol Transport
Phosphatidylcholine Acyl-chain Remodeling
Cholesterol Homeostasis
MRNA Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Negative Regulation Of Pinocytosis
Negative Regulation Of Inflammatory Response
Lipid Homeostasis
Negative Regulation Of Type II Interferon-mediated Signaling Pathway
Positive Regulation Of High-density Lipoprotein Particle Assembly
Positive Regulation Of Pancreatic Juice Secretion
Positive Regulation Of Secretion Of Lysosomal Enzymes
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways
PPARA activates gene expression
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
VLDLR internalisation and degradation
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
GW-3965
Benzenesulfinic acid
TO-901317
1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
Diacerein
Rhein
Diseases
GWAS
Femur bone mineral density x serum urate levels interaction (
34046847
)
Hip circumference adjusted for BMI (
25673412
34021172
)
Hip index (
34021172
)
Platelet count (
32888494
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Waist-to-hip ratio adjusted for body mass index (
25673412
)
Interacting Genes
24 interacting genes:
AKAP17A
CREBBP
EPM2A
H3-4
HABP4
INO80B
JMJD6
LENG8
MX1
NKAPD1
NR1H2
PIAS2
SRPK2
STAC3
STRBP
SUMO2
TENT5B
TNNT1
TSC22D1
TSPYL2
UBE2I
UBL5
UROD
ZCCHC10
52 interacting genes:
BAG6
CDKN1A
CHD3
COL4A5
CSAD
DNMT3L
DUSP12
ERG28
FAF1
FOXO3
HDAC4
HMGXB4
ING3
KDM1A
LAMC3
MDFI
MED1
MPP1
NCOA1
NCOA3
NCOA6
NCOR1
NCOR2
NPY
NR0B2
NRIP1
PCDH17
PPARA
PPARD
PPARG
PRKCA
RARA
RHOU
RMI1
ROBO2
RXRA
RXRB
RXRG
SCG5
SIRT1
SMPD1
SORBS2
SPRY2
SUV39H1
TMEM161A
TTC3
UBE2D1
UBE2I
VDR
VIM
YY1
ZXDC
Entrez ID
10042
7376
HPRD ID
05267
02660
Ensembl ID
ENSG00000100281
ENSG00000131408
Uniprot IDs
Q7Z641
Q9UGU5
F1D8P7
P55055
PDB IDs
1P8D
1PQ6
1PQ9
1PQC
1UPV
1UPW
3KFC
3L0E
4DK7
4DK8
4NQA
4RAK
5HJP
5I4V
5JY3
5KYA
5KYJ
6JIO
6K9G
6K9H
6K9M
6S4N
6S4T
6S4U
6S5K
Enriched GO Terms of Interacting Partners
?
SUMO Transferase Activity
Protein Sumoylation
Protein Tag Activity
Regulation Of RNA Splicing
RNA Splicing
MRNA Metabolic Process
Nuclear Body Organization
Nucleus
Chromatin Remodeling
Nucleic Acid Metabolic Process
PML Body
MRNA Processing
Voltage-gated Calcium Channel Complex
Nucleoplasm
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Binding
Presynaptic Cytosol
Postsynaptic Cytosol
RNA Metabolic Process
Slow-twitch Skeletal Muscle Fiber Contraction
Skeletal Muscle Contraction
SUMO Conjugating Enzyme Activity
Positive Regulation Of Secretion Of Lysosomal Enzymes
Uroporphyrinogen Decarboxylase Activity
Carbohydrate Phosphatase Activity
Histone H4R3 Demethylase Activity
Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine
Peptidyl-lysine 5-dioxygenase Activity
Histone H3R2 Demethylase Activity
Oxidative RNA Demethylation
Chromatin Organization
Nuclear Receptor-mediated Signaling Pathway
Nuclear Retinoid X Receptor Binding
Negative Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Hormone-mediated Signaling Pathway
Nuclear Receptor Binding
Chromatin
Negative Regulation Of MiRNA Transcription
Nuclear Receptor Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Nuclear Steroid Receptor Activity
Regulation Of MiRNA Transcription
Intracellular Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Steroid Hormone Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
MRNA Transcription By RNA Polymerase II
Peroxisome Proliferator Activated Receptor Signaling Pathway
RNA Polymerase II Transcription Regulator Complex
Regulation Of Primary Metabolic Process
Regulation Of MiRNA Metabolic Process
Regulation Of RNA Metabolic Process
Nucleoplasm
MRNA Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Response To Nutrient Levels
Response To Lipid
Nuclear Retinoic Acid Receptor Binding
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Retinoic Acid-responsive Element Binding
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Rhythmic Process
Transcription Cis-regulatory Region Binding
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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