TNNC1 and POLR2G

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TNNC1	POLR2G
Description		troponin C1, slow skeletal and cardiac type	RNA polymerase II subunit G
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GO Annotations	Cellular Component	Cytosol Troponin Complex Sarcomere Contractile Muscle Fiber Cardiac Troponin Complex	DNA-directed RNA Polymerase Complex P-body Nucleus Nucleoplasm RNA Polymerase II, Core Complex
	Molecular Function	Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding	Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Translation Initiation Factor Binding
	Biological Process	Diaphragm Contraction Skeletal Muscle Contraction Regulation Of Muscle Contraction Response To Metal Ion Transition Between Fast And Slow Fiber Muscle Filament Sliding Regulation Of Muscle Filament Sliding Speed Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Cardiac Muscle Cell Contraction	Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways		Striated Muscle Contraction	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs		Trifluoperazine Levosimendan Felodipine Bepridil Calcium Aluminium monostearate 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Feeling worry ( 29500382) Schizophrenia ( 23974872) Waist-to-hip ratio adjusted for BMI ( 34021172)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: CDK1 MST1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TRIM63 UBC UBE2C	45 interacting genes: ATF7IP BCL2L15 C22orf15 CIB3 CNTNAP2 DDX54 DES DUSP29 EIF3D EIF4A3 EWSR1 FNDC4 FOSL2 GPKOW HOXC5 KIF5B LMO2 MAPK1 MCM3AP MCPH1 MYOD1 NOTCH2NLA NTRK2 OSGIN1 PARVG POLR1C POLR2A POLR2C POLR2D POLR2E POLR2F POLR2H PRKRA PSMB8 RPAP1 TAF15 TNNC1 TRAPPC2L TRIM14 TRIM68 TSEN15 UPRT VHL WHR1 ZNF410
Entrez ID		7134	5436
HPRD ID		08930	15995
Ensembl ID		ENSG00000114854	ENSG00000168002
Uniprot IDs		P63316 Q6FH91	P62487
PDB IDs		1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 2MKP 2MLE 2MLF 2MZP 2N79 2N7L 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI 7SC2 7SC3 7SUP 7SVC 7SWG 7SWI 7SXC 7SXD 7UH9 7UHA 7UTI 7UTL 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT	2C35 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		Troponin Complex Troponin T Binding Striated Muscle Contraction Muscle Contraction Skeletal Muscle Contraction Muscle System Process Cardiac Muscle Contraction Regulation Of Muscle System Process Cardiac Troponin Complex Troponin C Binding Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Muscle Contraction Cardiac Muscle Tissue Morphogenesis Transition Between Fast And Slow Fiber Cardiac Myofibril Muscle Tissue Morphogenesis Regulation Of Skeletal Muscle Adaptation Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Tropomyosin Binding Regulation Of System Process Muscle Filament Sliding Actin-myosin Filament Sliding Actin Binding Regulation Of ATP-dependent Activity Actin-mediated Cell Contraction Sarcomere Organization System Process Pronuclear Fusion Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Actin Filament-based Movement Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Spermatocyte Division Protein Polymerization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Striated Muscle Contraction Troponin I Binding Positive Regulation Of Exit From Mitosis LncRNA Transcription	DNA-directed RNA Polymerase Complex RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Activity RNA Polymerase I Complex RNA Polymerase III Complex Nucleoplasm Transcription By RNA Polymerase II DNA-templated Transcription Nucleus Cerebral Cortex Development Nucleolus RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus Outer Ear Morphogenesis Macromolecule Biosynthetic Process Transcription Coregulator Activity TRNA Transcription By RNA Polymerase III TRNA Transcription Contractile Muscle Fiber Macromolecule Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Striatum Development Transcription By RNA Polymerase I DNA Binding
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