TNNC1 and TCP10L

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TNNC1	TCP10L
Description		troponin C1, slow skeletal and cardiac type	t-complex 10 like
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex Sarcomere Contractile Muscle Fiber Cardiac Troponin Complex	Nucleus
	Molecular Function	Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding	Transcription Corepressor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Diaphragm Contraction Skeletal Muscle Contraction Regulation Of Muscle Contraction Response To Metal Ion Transition Between Fast And Slow Fiber Muscle Filament Sliding Regulation Of Muscle Filament Sliding Speed Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Cardiac Muscle Cell Contraction	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Striated Muscle Contraction
Drugs		Trifluoperazine Levosimendan Felodipine Bepridil Calcium Aluminium monostearate 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Feeling worry ( 29500382) Schizophrenia ( 23974872) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: CDK1 MST1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TRIM63 UBC UBE2C	33 interacting genes: APP CATSPERT CCDC102B CCDC57 CCDC70 CDR2L CIAO1 DAPK3 FBXO25 FHL2 FRS3 IKBKG LMO1 LMO2 LMO3 LRRK2 MAPK9 MFAP1 MXD4 NCK2 NTAQ1 NXF1 PMF1 PRPH RALBP1 SAAL1 SMARCD1 TCEANC TNNC1 TNS2 TRIM55 TRIM63 TSSK3
Entrez ID		7134	140290
HPRD ID		08930	10518
Ensembl ID		ENSG00000114854	ENSG00000242220
Uniprot IDs		P63316 Q6FH91	Q8TDR4
PDB IDs		1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 2MKP 2MLE 2MLF 2MZP 2N79 2N7L 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI 7SC2 7SC3 7SUP 7SVC 7SWG 7SWI 7SXC 7SXD 7UH9 7UHA 7UTI 7UTL 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT
Enriched GO Terms of Interacting Partners?		Troponin Complex Troponin T Binding Striated Muscle Contraction Muscle Contraction Skeletal Muscle Contraction Muscle System Process Cardiac Muscle Contraction Regulation Of Muscle System Process Cardiac Troponin Complex Troponin C Binding Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Muscle Contraction Cardiac Muscle Tissue Morphogenesis Transition Between Fast And Slow Fiber Cardiac Myofibril Muscle Tissue Morphogenesis Regulation Of Skeletal Muscle Adaptation Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Tropomyosin Binding Regulation Of System Process Muscle Filament Sliding Actin-myosin Filament Sliding Actin Binding Regulation Of ATP-dependent Activity Actin-mediated Cell Contraction Sarcomere Organization System Process Pronuclear Fusion Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Actin Filament-based Movement Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Spermatocyte Division Protein Polymerization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Striated Muscle Contraction Troponin I Binding Positive Regulation Of Exit From Mitosis LncRNA Transcription	Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Manganese Ion Negative Regulation Of Response To Endoplasmic Reticulum Stress
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