TNNC1 and TCP10L

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TNNC1	TCP10L
Gene Name		troponin C type 1 (slow)	t-complex 10-like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Troponin Complex Actin Cytoskeleton	Nucleus
	Molecular Function	Calcium Ion Binding Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Calcium-dependent Protein Binding Actin Filament Binding	RNA Polymerase II Transcription Corepressor Activity Protein Binding Identical Protein Binding Protein Self-association Repressing Transcription Factor Binding
	Biological Process	Diaphragm Contraction Regulation Of Muscle Contraction Response To Metal Ion Muscle Filament Sliding Regulation Of Muscle Filament Sliding Speed Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways		Striated Muscle Contraction
Drugs		Trifluoperazine Levosimendan Felodipine Bepridil Calcium Dihydroxyaluminium 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		11 interactors: CDK1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TRIM63 UBE2C	7 interactors: APP DAPK3 FBXO25 IKBKG MXD4 PMF1 TNNC1
Entrez ID		7134	140290
HPRD ID		08930	10518
Ensembl ID		ENSG00000114854
Uniprot IDs		P63316 Q6FH91	Q8TDR4 Q9NV44
PDB IDs		1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Negative Regulation Of ATPase Activity Actin Filament-based Process Striated Muscle Contraction Striated Muscle Tissue Development Muscle Tissue Development Cardiac Ventricle Development Movement Of Cell Or Subcellular Component Cardiac Chamber Development Muscle Structure Development Heart Development Skeletal Muscle Contraction Heart Morphogenesis Regulation Of ATPase Activity Musculoskeletal Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Muscle Organ Development Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Cardiovascular System Development Pronuclear Fusion Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of MRNA Processing Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Free Ubiquitin Chain Polymerization Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Smooth Muscle Contraction Regulation Of Muscle Filament Sliding Speed Synaptic Growth At Neuromuscular Junction Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Muscle Filament Sliding Regulation Of Myosin II Filament Organization Regulation Of Muscle Contraction Gene Expression Diaphragm Contraction Innate Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Involuntary Skeletal Muscle Contraction Intracellular Receptor Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Apoptotic Process Programmed Cell Death Transcription, DNA-templated Negative Regulation Of ATPase Activity Cell Death Death Neuron Remodeling Regulation Of Translation RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Calcium Ion Homeostasis Regulation Of RNA Biosynthetic Process Calcium Ion Homeostasis Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Respiratory System Process Immune Response Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Defense Response Regulation Of Gene Expression Cellular Copper Ion Homeostasis Regulation Of Nitrogen Compound Metabolic Process Homeostatic Process Negative Regulation Of Hydrolase Activity Regulation Of Actin Filament-based Process Cellular Metal Ion Homeostasis Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process
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