MST1 and TNNT2

Number of citations of the paper that reports this interaction (PubMedID 18986304)
37

Data Source:
BioGRID (enzymatic study)

		MST1	TNNT2
Description		macrophage stimulating 1	troponin T2, cardiac type
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Endopeptidase Activity Protein Binding Receptor Tyrosine Kinase Binding	Microfilament Motor Activity Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Troponin I Binding Identical Protein Binding
	Biological Process	Proteolysis Negative Regulation Of Gluconeogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Macromolecule Metabolic Process Regulation Of CAMP-dependent Protein Kinase Activity	Regulation Of Muscle Contraction Striated Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATP-dependent Activity Positive Regulation Of ATP-dependent Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Signaling by MST1	Striated Muscle Contraction
Drugs
Diseases			Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 17554300 28067908 17554261 18587394 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 23128233 28067908) Primary sclerosing cholangitis ( 27992413 21151127 23603763) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 20228799 28067908 25082827 19915572 21297633)	Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)
Interacting Genes		10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2	16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69
Entrez ID		4485	7139
HPRD ID		00798	01844
Ensembl ID		ENSG00000173531	ENSG00000118194
Uniprot IDs		G3XAK1 P26927 Q53GN8	A0AAQ5BHX3 P45379 Q15607
PDB IDs		2ASU 4QT8	1J1D 1J1E 4Y99 6KN7 6KN8 7UTI 7UTL 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT
Enriched GO Terms of Interacting Partners?		Cardiac Troponin Complex Troponin Complex Muscle Filament Sliding Actin-myosin Filament Sliding Regulation Of Muscle System Process Troponin C Binding Actin-mediated Cell Contraction Troponin I Binding Troponin T Binding Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Sarcomere Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Cardiac Myofibril Regulation Of System Process Muscle Tissue Morphogenesis Striated Muscle Contraction Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Regulation Of Muscle Contraction Regulation Of ATP-dependent Activity Skeletal Muscle Contraction Muscle Contraction Muscle System Process Regulation Of Muscle Filament Sliding Speed Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Response To Aluminum Ion Regulation Of Cardiac Muscle Hypertrophy Response To Metal Ion Positive Regulation Of Protein Metabolic Process Calcium-dependent Protein Binding Factor XII Activation Macrophage Colony-stimulating Factor Receptor Activity Tissue Morphogenesis Actin Filament-based Process Diaphragm Contraction Regulation Of Muscle Filament Sliding Response To Aluminum Ion Positive Regulation Of Fibrinolysis Macrophage Colony-stimulating Factor Signaling Pathway Involuntary Skeletal Muscle Contraction Phosphatidylinositol 3-kinase Complex, Class III, Type II Negative Regulation Of Lysosome Organization Cellular Response To Oxygen-glucose Deprivation Phosphatidylinositol 3-kinase Complex, Class III, Type I Regulation Of Multicellular Organismal Process Cellular Response To Hyperoxia Cytoplasmic Side Of Mitochondrial Outer Membrane Response To Mitochondrial Depolarisation	Troponin Complex Troponin T Binding Striated Muscle Contraction Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Regulation Of Muscle System Process Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Skeletal Muscle Adaptation Cardiac Muscle Tissue Morphogenesis Regulation Of System Process Muscle Filament Sliding Regulation Of Muscle Contraction Actin-myosin Filament Sliding Muscle Tissue Morphogenesis Muscle Contraction Cardiac Troponin Complex Muscle System Process Actin-mediated Cell Contraction Regulation Of Smooth Muscle Cell Proliferation Sarcomere Actin Filament-based Movement Regulation Of Double-strand Break Repair Via Homologous Recombination Contractile Muscle Fiber Positive Regulation Of Smooth Muscle Cell Proliferation Anatomical Structure Morphogenesis System Process Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Double-strand Break Repair Protein Homodimerization Activity Neuron Maturation Positive Regulation Of RNA Biosynthetic Process Enzyme Binding Cytosol Positive Regulation Of DNA-templated Transcription Response To Reactive Oxygen Species Tissue Morphogenesis Actin Filament-based Process Sarcomere Organization Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Muscle Filament Sliding Speed Actin Filament Binding
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