MST1 and FOXO1

Number of citations of the paper that reports this interaction (PubMedID 18786403)
60

Data Source:
BioGRID (enzymatic study)

		MST1	FOXO1
Description		macrophage stimulating 1	forkhead box O1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Endopeptidase Activity Protein Binding Receptor Tyrosine Kinase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding Promoter-specific Chromatin Binding
	Biological Process	Proteolysis Negative Regulation Of Gluconeogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Macromolecule Metabolic Process Regulation Of CAMP-dependent Protein Kinase Activity	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Temperature Homeostasis Intracellular Glucose Homeostasis Gluconeogenesis Regulation Of Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Autophagy Apoptotic Process DNA Damage Response Insulin Receptor Signaling Pathway Cellular Response To Starvation Gene Expression Positive Regulation Of Autophagy Cell Differentiation Response To Insulin Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Cell Population Proliferation Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Canonical Wnt Signaling Pathway Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To Cold Response To Fatty Acid Cellular Response To Hyperoxia Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Energy Homeostasis Neuronal Stem Cell Population Maintenance Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Signaling by MST1	AKT phosphorylates targets in the nucleus Regulation of gene expression in beta cells AKT-mediated inactivation of FOXO1A Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes
Drugs
Diseases			Alveolar rhabdomyosarcoma
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 17554300 28067908 17554261 18587394 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 23128233 28067908) Primary sclerosing cholangitis ( 27992413 21151127 23603763) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 20228799 28067908 25082827 19915572 21297633)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Central corneal thickness ( 32528159 29760442 20485516 31798171 20719862) Corneal hysteresis ( 32716492 31246245 30894546) Corneal resistance factor ( 32716492 31246245 30894546) Corneal structure ( 23291589) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) Intraocular pressure ( 29617998 29235454) Mean corpuscular hemoglobin ( 32888494 29403010 27863252) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010) Sum eosinophil basophil counts ( 27863252) Uterine fibroids ( 31649266 30194396) Weight ( 28552196)
Interacting Genes		10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2	39 interacting genes: AKT1 AR CDK1 CEBPB CREBBP CSNK1G1 CTNNB1 DACH1 DANCR DYRK1A ESR1 FHL2 FOXG1 G6PC1 GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 NCOA1 NEDD4L PAK1 PARP1 PIK3R3 PITX1 PPARG RARA SET SFN SIRT1 SMAD3 SMAD4 SRC THRB TNS2 YWHAG YWHAZ
Entrez ID		4485	2308
HPRD ID		00798	00645
Ensembl ID		ENSG00000173531	ENSG00000150907
Uniprot IDs		G3XAK1 P26927 Q53GN8	Q12778
PDB IDs		2ASU 4QT8	3CO6 3CO7 3COA 4LG0 5DUI 6LBI 6QVW 6QZR 6QZS 8A62 8A65
Enriched GO Terms of Interacting Partners?		Cardiac Troponin Complex Troponin Complex Muscle Filament Sliding Actin-myosin Filament Sliding Regulation Of Muscle System Process Troponin C Binding Actin-mediated Cell Contraction Troponin I Binding Troponin T Binding Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Sarcomere Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Cardiac Myofibril Regulation Of System Process Muscle Tissue Morphogenesis Striated Muscle Contraction Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Regulation Of Muscle Contraction Regulation Of ATP-dependent Activity Skeletal Muscle Contraction Muscle Contraction Muscle System Process Regulation Of Muscle Filament Sliding Speed Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Response To Aluminum Ion Regulation Of Cardiac Muscle Hypertrophy Response To Metal Ion Positive Regulation Of Protein Metabolic Process Calcium-dependent Protein Binding Factor XII Activation Macrophage Colony-stimulating Factor Receptor Activity Tissue Morphogenesis Actin Filament-based Process Diaphragm Contraction Regulation Of Muscle Filament Sliding Response To Aluminum Ion Positive Regulation Of Fibrinolysis Macrophage Colony-stimulating Factor Signaling Pathway Involuntary Skeletal Muscle Contraction Phosphatidylinositol 3-kinase Complex, Class III, Type II Negative Regulation Of Lysosome Organization Cellular Response To Oxygen-glucose Deprivation Phosphatidylinositol 3-kinase Complex, Class III, Type I Regulation Of Multicellular Organismal Process Cellular Response To Hyperoxia Cytoplasmic Side Of Mitochondrial Outer Membrane Response To Mitochondrial Depolarisation	Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Response To Hormone Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Differentiation Animal Organ Development Regulation Of Protein Localization Chromatin Transcription Regulator Complex Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Developmental Process Transcription Coactivator Binding Negative Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Negative Regulation Of Programmed Cell Death Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation
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