MST1 and KLKB1

Number of citations of the paper that reports this interaction (PMID 10068459)
0

Data Source:
HPRD (in vitro)

		MST1	KLKB1
Gene Name		macrophage stimulating 1 (hepatocyte growth factor-like)	kallikrein B, plasma (Fletcher factor) 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Serine-type Endopeptidase Activity	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Proteolysis Spermatogenesis Embryo Implantation Biological_process Sperm Motility	Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis
Pathways			Intrinsic Pathway Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS		Crohn's disease ( 18587394 17554261 17554300 21102463) Inflammatory bowel disease ( 23128233) Primary sclerosing cholangitis ( 21151127) Ulcerative colitis ( 19915572 20228799 21297633)	Circulating vasoactive peptide levels ( 23381795) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Obesity-related traits ( 23251661) Response to statin therapy ( 20339536)
Protein-Protein Interactions		8 interactors: DAXX FOXO1 HIST2H2BE KLKB1 MOB1A MST1R RASSF1 SERPINA3	8 interactors: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2
Entrez ID		4485	3818
HPRD ID		00798	01971
Ensembl ID		ENSG00000173531	ENSG00000164344
Uniprot IDs		G3XAK1 P26927 Q53GN8	P03952
PDB IDs		2ASU	2ANW 2ANY
Enriched GO Terms of Interacting Partners?		Response To Stress Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response Response To Stimulus Acute Inflammatory Response Factor XII Activation Nucleosome Assembly Chromatin Assembly Regulation Of MAPK Cascade Macrophage Colony-stimulating Factor Signaling Pathway Nucleosome Organization Chromatin Assembly Or Disassembly Positive Regulation Of Fibrinolysis Protein-DNA Complex Assembly DNA Packaging Regulation Of Stress-activated MAPK Cascade Innate Immune Response Regulation Of Protein Ubiquitination Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Cellular Response To Cold Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Macrophage Colony-stimulating Factor Stimulus Multicellular Organismal Homeostasis Positive Regulation Of Protein Modification Process Plasminogen Activation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Plasma Kallikrein-kinin Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Conformation Change Regulation Of Energy Homeostasis Regulation Of MAP Kinase Activity Cellular Response To Nitric Oxide Regulation Of Fibrinolysis Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation, Intrinsic Pathway Maintenance Of Gastrointestinal Epithelium Response To Nitric Oxide Innate Immune Response In Mucosa Positive Regulation Of Gluconeogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Processing Epithelial Structure Maintenance Immune Response Regulation Of Phosphorylation Regulation Of Protein Processing Cellular Response To Reactive Nitrogen Species	Regulation Of Protein Processing Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Response To Wounding Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Blood Coagulation, Intrinsic Pathway Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Cellular Metabolic Process Platelet Degranulation Regulation Of Blood Coagulation Factor XII Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Wound Healing Positive Regulation Of Cell Death Regulation Of Cell Death Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Positive Regulation Of Fibrinolysis Protein Activation Cascade Positive Regulation Of Plasminogen Activation Regulation Of Metabolic Process Platelet Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Response To Stress Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Primitive Hemopoiesis
Tagcloud ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mbp mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad	0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed logarithmically lvm motivate natriuretic nppb relations residuals rs198389 rs3733402 whites
Tagcloud (Difference) ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mbp mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad	0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed logarithmically lvm motivate natriuretic nppb relations residuals rs198389 rs3733402 whites
Tagcloud (Intersection) ?