MST1 and SERPINA3

Number of citations of the paper that reports this interaction (PMID 11274154)
3

Data Source:
HPRD (in vitro)

		MST1	SERPINA3
Gene Name		macrophage stimulating 1 (hepatocyte growth factor-like)	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Molecular_function Serine-type Endopeptidase Activity	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Spermatogenesis Embryo Implantation Biological_process Sperm Motility	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 18587394 17554261 17554300 21102463) Inflammatory bowel disease ( 23128233) Primary sclerosing cholangitis ( 21151127) Ulcerative colitis ( 19915572 20228799 21297633)	Body mass index ( 23669352)
Protein-Protein Interactions		8 interactors: DAXX FOXO1 HIST2H2BE KLKB1 MOB1A MST1R RASSF1 SERPINA3	25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		4485	12
HPRD ID		00798	00120
Ensembl ID		ENSG00000173531	ENSG00000196136
Uniprot IDs		G3XAK1 P26927 Q53GN8	G3V5I3 P01011
PDB IDs		2ASU	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA
Enriched GO Terms of Interacting Partners?		Response To Stress Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response Response To Stimulus Acute Inflammatory Response Factor XII Activation Nucleosome Assembly Chromatin Assembly Regulation Of MAPK Cascade Macrophage Colony-stimulating Factor Signaling Pathway Nucleosome Organization Chromatin Assembly Or Disassembly Positive Regulation Of Fibrinolysis Protein-DNA Complex Assembly DNA Packaging Regulation Of Stress-activated MAPK Cascade Innate Immune Response Regulation Of Protein Ubiquitination Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Cellular Response To Cold Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Macrophage Colony-stimulating Factor Stimulus Multicellular Organismal Homeostasis Positive Regulation Of Protein Modification Process Plasminogen Activation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Plasma Kallikrein-kinin Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Conformation Change Regulation Of Energy Homeostasis Regulation Of MAP Kinase Activity Cellular Response To Nitric Oxide Regulation Of Fibrinolysis Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation, Intrinsic Pathway Maintenance Of Gastrointestinal Epithelium Response To Nitric Oxide Innate Immune Response In Mucosa Positive Regulation Of Gluconeogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Processing Epithelial Structure Maintenance Immune Response Regulation Of Phosphorylation Regulation Of Protein Processing Cellular Response To Reactive Nitrogen Species	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response
Tagcloud ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mbp mst2 myelin okadaic originally p36 peroxide programmed proteases ste20 streptomyces virtue yvad	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Difference) ?		ac acetylcysteine antioxidants asp budding caspases ch2 cho cytotrienin dcb devd h2o2 hl immunologically krs1 krs2 mbp mst2 myelin okadaic originally p36 peroxide programmed ste20 streptomyces virtue yvad	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment question remodeling resultsthe submitted supported
Tagcloud (Intersection) ?		proteases