MST1 and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 11274154)
0

Data Source:
HPRD (in vitro)

		MST1	SERPINA3
Description		macrophage stimulating 1	serpin family A member 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Activity Protein Binding Receptor Tyrosine Kinase Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Negative Regulation Of Gluconeogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Macromolecule Metabolic Process Regulation Of CAMP-dependent Protein Kinase Activity	Acute-phase Response Inflammatory Response Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Response To Cytokine
Pathways		Signaling by MST1	Platelet degranulation Neutrophil degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 17554300 28067908 17554261 18587394 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 23128233 28067908) Primary sclerosing cholangitis ( 27992413 21151127 23603763) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 20228799 28067908 25082827 19915572 21297633)	Blood protein levels ( 30072576) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein levels ( 29403010)
Interacting Genes		10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2	29 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CFTR CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 HSP90AA1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD
Entrez ID		4485	12
HPRD ID		00798	00120
Ensembl ID		ENSG00000173531	ENSG00000196136
Uniprot IDs		G3XAK1 P26927 Q53GN8	P01011
PDB IDs		2ASU 4QT8	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE 9C2T 9D7K
Enriched GO Terms of Interacting Partners?		Cardiac Troponin Complex Troponin Complex Muscle Filament Sliding Actin-myosin Filament Sliding Regulation Of Muscle System Process Troponin C Binding Actin-mediated Cell Contraction Troponin I Binding Troponin T Binding Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Sarcomere Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Cardiac Myofibril Regulation Of System Process Muscle Tissue Morphogenesis Striated Muscle Contraction Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Regulation Of Muscle Contraction Regulation Of ATP-dependent Activity Skeletal Muscle Contraction Muscle Contraction Muscle System Process Regulation Of Muscle Filament Sliding Speed Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Response To Aluminum Ion Regulation Of Cardiac Muscle Hypertrophy Response To Metal Ion Positive Regulation Of Protein Metabolic Process Calcium-dependent Protein Binding Factor XII Activation Macrophage Colony-stimulating Factor Receptor Activity Tissue Morphogenesis Actin Filament-based Process Diaphragm Contraction Regulation Of Muscle Filament Sliding Response To Aluminum Ion Positive Regulation Of Fibrinolysis Macrophage Colony-stimulating Factor Signaling Pathway Involuntary Skeletal Muscle Contraction Phosphatidylinositol 3-kinase Complex, Class III, Type II Negative Regulation Of Lysosome Organization Cellular Response To Oxygen-glucose Deprivation Phosphatidylinositol 3-kinase Complex, Class III, Type I Regulation Of Multicellular Organismal Process Cellular Response To Hyperoxia Cytoplasmic Side Of Mitochondrial Outer Membrane Response To Mitochondrial Depolarisation	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Secretory Granule Proteolysis Extracellular Region Endopeptidase Activity Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Space Protein Metabolic Process Macromolecule Metabolic Process Extracellular Matrix Protein Maturation Protein Processing Amelogenesis Defense Response To Fungus ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Defense Response To Bacterium Response To Fungus Neutrophil-mediated Killing Of Bacterium Glial Cell Development Angiotensin Maturation Protein-containing Complex Localization Response To Yeast Platelet Alpha Granule Protein Catabolic Process Response To Bacterium Neutrophil Mediated Immunity Protein-folding Chaperone Binding Basolateral Plasma Membrane Amyloid-beta Complex Monoatomic Ion Homeostasis Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Monoatomic Cation Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Biofilm Matrix Disassembly Killing By Host Of Symbiont Cells Glycoprotein Catabolic Process Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Positive Regulation Of MAP Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Myelin Sheath
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