TMPO and AKAP8L

Number of citations of the paper that reports this interaction (PubMedID 12538639)
38

Data Source:
HPRD (in vitro)

		TMPO	AKAP8L
Description		thymopoietin	A-kinase anchoring protein 8 like
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Chromosome Cytoplasm Membrane Nuclear Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Nuclear Speck Ribonucleoprotein Complex
	Molecular Function	DNA Binding Protein Binding Lamin Binding Cadherin Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Zinc Ion Binding DEAD/H-box RNA Helicase Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding
	Biological Process		MRNA Processing Mitotic Chromosome Condensation RNA Splicing Regulation Of MRNA Export From Nucleus Cell Cycle G2/M Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Nuclear Membrane Disassembly
Pathways		RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Red blood cell count ( 32888494)
Interacting Genes		27 interacting genes: ABL1 AKAP8L BANF1 CDK1 CEBPA CLK1 CSNK2A1 FXR1 GMCL1 GOLM1 HDAC3 KLHL6 LMNA LMNB1 LMNB2 OGT OIP5 RB1 RNF123 SGTA SGTB SRC SRPK2 STOM SUMO2 USP7 WEE2-AS1	60 interacting genes: ABI2 ATOSB ATPAF2 CARHSP1 CATSPER1 CCDC120 CCDC24 CDC6 CNNM3 CREB5 CSTF2 CSTF2T DGCR6 DHX9 DMRT3 DSCR9 EMD ENKD1 FOXD4 GPANK1 GPS2 HEMK1 HGS HSF4 HUNK INCA1 KPRP LAGE3 LBR MYOZ1 MYPOP PATZ1 PCDHB14 PEF1 PITX1 PLEKHN1 PRKAA2 PRKACA PRPF40A PTP4A2 RAMAC RTP5 RUSC1 SAMD4A SAXO1 SAXO4 SH3RF2 SNRPC TEKT4 TEKT5 TENT5B TFAP2D TIAL1 TLE5 TMPO TMSB4X TRIB3 TSGA10IP WDR25 ZNF366
Entrez ID		7112	26993
HPRD ID		01777	10641
Ensembl ID		ENSG00000120802	ENSG00000011243
Uniprot IDs		G5E972 P42166 P42167 Q59G12	Q9ULX6
PDB IDs		1GJJ 1H9E 1H9F 8FN7 8FND 8FNG 8FNH 8FNJ 8FNL 8FNM 8FNN 8FNO 8FNP 8FNQ
Enriched GO Terms of Interacting Partners?		Nuclear Pore Localization Nucleus Organization Negative Regulation Of Gene Expression, Epigenetic Organelle Organization Chromatin Organization Nuclear Envelope Organization Negative Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Chromatin Remodeling Regulation Of Proteasomal Protein Catabolic Process PML Body Nuclear Lamina Negative Regulation Of Macromolecule Biosynthetic Process Protein Localization To Nuclear Envelope Negative Regulation Of Biosynthetic Process Nuclear Matrix Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Structural Constituent Of Nuclear Lamina TRC Complex Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Localization Regulation Of Gene Expression Protein Localization To Organelle Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Nuclear Migration Regulation Of Cellular Localization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Nucleus Localization Cellular Response To Fluid Shear Stress Nucleus Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Nuclear Envelope Rb-E2F Complex Lamin Filament Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process	Protein Binding Sperm Flagellum
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