TMPO and LMNB1

Number of citations of the paper that reports this interaction (PMID 9490046)
7

Data Source:
HPRD (two hybrid, in vitro)

		TMPO	LMNB1
Gene Name		thymopoietin	lamin B1
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Cytoplasm Membrane Integral Component Of Membrane Nuclear Membrane	Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Membrane
	Molecular Function	DNA Binding Protein Binding Lamin Binding	Structural Molecule Activity Phospholipase Binding
	Biological Process	Regulation Of Transcription, DNA-templated	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Pathways			Apoptotic cleavage of cellular proteins DNA Damage/Telomere Stress Induced Senescence Mitotic Prophase Apoptotic execution phase Cellular Senescence Meiotic synapsis Depolymerisation of the Nuclear Lamina Nuclear Envelope Breakdown Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase M Phase Cell Cycle, Mitotic Formation of Senescence-Associated Heterochromatin Foci (SAHF) Programmed Cell Death Breakdown of the nuclear lamina Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Parkinson's disease (motor and cognition) ( 22658654)
Protein-Protein Interactions		13 interactors: AKAP8L BANF1 CSNK2A1 GMCL1 HDAC3 LMNA LMNB1 LMNB2 OIP5 RB1 SGTA SGTB USP7	23 interactors: ABCG8 ATF4 CASP3 CASP6 CDK1 GIT2 GZMA GZMB LBR LMNA MBIP MELK PLEC PRKCA PRKCB PRKCD PRPH SERPINA3 SUMO4 TMPO TOR1AIP1 URB2 YWHAQ
Entrez ID		7112	4001
HPRD ID		01777	01036
Ensembl ID		ENSG00000120802	ENSG00000113368
Uniprot IDs		G5E972 P42166 P42167 Q59G12	B4DZT3 P20700
PDB IDs		1GJJ 1H9E 1H9F	2KPW 3JT0 3TYY 3UMN
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Mitotic Nuclear Envelope Reassembly Mitotic Cell Cycle Process Nuclear Envelope Reassembly Mitotic Cell Cycle Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Viral Process Mitotic Nuclear Envelope Disassembly Chromatin Modification Nuclear Envelope Disassembly Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Metaphase/anaphase Transition Chromatin Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Envelope Organization Sterol Regulatory Element Binding Protein Import Into Nucleus Execution Phase Of Apoptosis Regulation Of Chromosome Segregation Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Apoptotic Process Programmed Cell Death Chromosome Organization Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Cell Death Death Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleus Organization Regulation Of Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Checkpoint Chromatin Remodeling Positive Regulation Of Mitotic Metaphase/anaphase Transition Maintenance Of DNA Methylation Glial Cell Apoptotic Process	Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Envelope Organization Execution Phase Of Apoptosis Apoptotic Signaling Pathway Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Nucleus Organization Peptidyl-threonine Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Histone H3-T6 Phosphorylation Positive Regulation Of Cell Death Cellular Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Histone Phosphorylation Peptidyl-amino Acid Modification Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Oxidative Stress Positive Regulation Of Catalytic Activity Endomembrane System Organization Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of MAP Kinase Activity Regulation Of Mitochondrion Organization Regulation Of Platelet Aggregation Membrane Organization Negative Regulation Of Glucose Transport Regulation Of Phosphorylation Regulation Of MAP Kinase Activity
Tagcloud ?		appearances barely cxxc5 deg degs egfl7 exclusions exon fhl1 foxm1 gains hub inclusions ingenuity ipa maz multilateral ndrg2 pah phh plk1 rcan1 reads seq signatures suddenly synpo transcriptomic ttll1	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Difference) ?		appearances barely cxxc5 deg degs egfl7 exclusions exon fhl1 foxm1 gains hub inclusions ingenuity ipa maz multilateral ndrg2 pah phh plk1 rcan1 reads seq signatures suddenly synpo transcriptomic ttll1	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Intersection) ?