TSPAN7 and SMO

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TSPAN7	SMO
Description		tetraspanin 7	smoothened, frizzled class receptor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Plasma Membrane Caveola Cilium Membrane Dendrite Endocytic Vesicle Membrane Cell Projection Ciliary Membrane Extracellular Exosome Ciliary Tip 9+0 Non-motile Cilium Plasma Membrane Bounded Cell Projection
	Molecular Function	Protein Binding	CAMP-dependent Protein Kinase Inhibitor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Patched Binding Protein Binding Oxysterol Binding Protein Kinase A Catalytic Subunit Binding Protein Sequestering Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Ossification Vasculogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Neural Crest Cell Migration Negative Regulation Of Protein Phosphorylation Hair Follicle Development Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Heart Morphogenesis Determination Of Left/right Asymmetry In Lateral Mesoderm Type B Pancreatic Cell Development Protein Import Into Nucleus Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Determination Of Left/right Symmetry Ventral Midline Determination Pattern Specification Process Neuroblast Proliferation Central Nervous System Development Midgut Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Tissue Development Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Spinal Cord Dorsal/ventral Patterning Dentate Gyrus Development Cerebellar Cortex Morphogenesis Thalamus Development Dorsal/ventral Neural Tube Patterning Central Nervous System Neuron Differentiation Cerebral Cortex Development Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Hair Follicle Morphogenesis Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Astrocyte Activation Cell Development Digestive Tract Development Embryonic Organ Development Developmental Growth Skeletal Muscle Fiber Development Smooth Muscle Tissue Development Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Protein Stabilization Myoblast Migration Negative Regulation Of Hair Follicle Development Contact Inhibition Atrial Septum Morphogenesis Mammary Gland Epithelial Cell Differentiation Epithelial-mesenchymal Cell Signaling Somite Development Pancreas Morphogenesis Left/right Axis Specification Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Response To Inositol Regulation Of Somatic Stem Cell Population Maintenance Regulation Of Heart Morphogenesis
Pathways		Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors	Class B/2 (Secretin family receptors) Hedgehog 'off' state BBSome-mediated cargo-targeting to cilium Hedgehog 'on' state Activation of SMO Activation of SMO
Drugs			Fluocinonide Halcinonide Vismodegib Sonidegib Glasdegib
Diseases		Non-syndromic X-linked mental retardation	Basal cell carcinoma
GWAS		White blood cell count ( 32888494)	Osteoarthritis (hip) ( 30374069)
Interacting Genes		27 interacting genes: ADRB2 BBS1 BTG3 BUD31 CACNA1A CCR2 CCR9 CHRM2 CHRM4 CREB3 DRD2 FAM209A FYTTD1 GNRHR GPR152 GPR35 GRIA2 GRIA3 HTR4 ITGB1 LHFPL5 LMNA LTB4R2 MEOX2 OXTR PICK1 SMO	28 interacting genes: ARLN ARV1 C18orf32 EMC10 FKBP8 GABARAPL2 GABBR1 HMGN4 HMOX1 HMOX2 ITGB1BP1 JPH3 LEPROT NDFIP1 NEDD4 NGEF NIPA1 PLPP7 PTCH1 PTCH2 RPN2 S1PR5 SLC41A3 SSPN TIMMDC1 TMCC2 TSPAN7 WLS
Entrez ID		7102	6608
HPRD ID		02107	03294
Ensembl ID		ENSG00000156298	ENSG00000128602
Uniprot IDs		P41732	Q99835
PDB IDs			4JKV 4N4W 4O9R 4QIM 4QIN 5L7D 5L7I 5V56 5V57 6OT0 6XBJ 6XBK 6XBL 6XBM 7ZI0
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Biological Quality Chemical Synaptic Transmission Plasma Membrane Trans-synaptic Signaling Synaptic Signaling Cell-cell Signaling Signaling Endocytic Vesicle Membrane Cell Communication Dendrite Chemokine Receptor Activity Multicellular Organismal-level Homeostasis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Binding Positive Regulation Of Neuroblast Proliferation Ionotropic Glutamate Receptor Signaling Pathway Neural Precursor Cell Proliferation G Protein-coupled Acetylcholine Receptor Activity Regulation Of Locomotion Postsynaptic Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane Positive Regulation Of Neurotransmitter Uptake AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Signaling Pathway Regulation Of Neuroblast Proliferation Neuroblast Proliferation Signal Transduction Patched Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Cellular Defense Response Glutamate Receptor Signaling Pathway Synapse Positive Regulation Of Neural Precursor Cell Proliferation Ciliary Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dendritic Spine Positive Regulation Of Cytosolic Calcium Ion Concentration Glutamate-gated Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Motility Regulation Of System Process Cilium	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Heme Oxidation Heme Oxygenase (decyclizing) Activity Hedgehog Family Protein Binding Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Dorsal/ventral Neural Tube Patterning Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Cell Fate Specification Magnesium Ion Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction
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