TSPAN7 and HTR4

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		TSPAN7	HTR4
Name		tetraspanin 7	5-hydroxytryptamine receptor 4
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	None	System Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Mucus Secretion Large Intestinal Transit Regulation Of Postsynapse Assembly
Pathways		Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors	Serotonin receptors G alpha (s) signalling events
Drugs		None	Dihydroergotamine Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases		Non-syndromic X-linked mental retardation	None
GWAS		White blood cell count ( 32888494 )	Airflow obstruction ( 22837378 ) Chronic obstructive pulmonary disease ( 30804561 28166215 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Diastolic blood pressure ( 30578418 ) FEV1 ( 30804560 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Lung function (FEV1) ( 28166213 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (FVC) ( 30804560 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011 ) Medication use (adrenergics, inhalants) ( 31015401 ) Mood instability ( 31168069 ) Peak expiratory flow ( 30804560 ) Periodontal microbiota ( 22699663 ) Pulmonary function ( 20010835 20010834 ) Pulmonary function (smoking interaction) ( 23284291 ) Systolic blood pressure ( 30578418 ) Urinary sodium excretion ( 31409800 )
Novel Interactors		1 novel interactors: RPGR	None recorded
Interacting Genes		27 interacting genes: ADRB2 BBS1 BTG3 BUD31 CACNA1A CCR2 CCR9 CHRM2 CHRM4 CREB3 DRD2 FAM209A FYTTD1 GNRHR GPR152 GPR35 GRIA2 GRIA3 HTR4 ITGB1 LHFPL5 LMNA LTB4R2 MEOX2 OXTR PICK1 SMO	18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
Entrez ID		7102	3360
HPRD ID		02107	09074
Ensembl ID		ENSG00000156298	ENSG00000164270
Uniprot IDs		P41732	A0A2D3FAF9 Q13639
PDB IDs		Not available	5EM9 7XT8 7XT9 7XTA
GO Terms Enriched among Interactors		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Biological Quality Chemical Synaptic Transmission Plasma Membrane Trans-synaptic Signaling Synaptic Signaling Cell-cell Signaling Signaling Endocytic Vesicle Membrane Cell Communication Dendrite Chemokine Receptor Activity Multicellular Organismal-level Homeostasis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Binding Positive Regulation Of Neuroblast Proliferation Ionotropic Glutamate Receptor Signaling Pathway Neural Precursor Cell Proliferation G Protein-coupled Acetylcholine Receptor Activity Regulation Of Locomotion Postsynaptic Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane Positive Regulation Of Neurotransmitter Uptake AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Signaling Pathway Regulation Of Neuroblast Proliferation Neuroblast Proliferation Signal Transduction Patched Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Cellular Defense Response Glutamate Receptor Signaling Pathway Synapse Positive Regulation Of Neural Precursor Cell Proliferation Ciliary Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dendritic Spine Positive Regulation Of Cytosolic Calcium Ion Concentration Glutamate-gated Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Motility Regulation Of System Process Cilium	Membrane Endoplasmic Reticulum Membrane