MASP2

Gene Name		mannan-binding lectin serine peptidase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: FCN2 MBL2 SERPING1
Entrez ID		10747
HPRD ID		05484
Ensembl ID		ENSG00000009724
Uniprot IDs		O00187
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 4FXG
Enriched GO Terms of Interacting Partners?		Complement Activation Complement Activation, Lectin Pathway Protein Activation Cascade Opsonization Humoral Immune Response Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Regulation Of Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Defense Response Defense Response To Bacterium Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Phagocytosis Leukocyte Mediated Immunity Adaptive Immune Response Immune System Process Recognition Of Apoptotic Cell Killing By Host Of Symbiont Cells Response To Bacterium Negative Regulation Of Complement Activation Blood Coagulation, Intrinsic Pathway Phagocytosis, Recognition Endocytosis Response To Other Organism Response To Biotic Stimulus Killing Of Cells Of Other Organism Response To Stress Negative Regulation Of Growth Of Symbiont In Host Fibrinolysis Regulation Of Complement Activation Apoptotic Cell Clearance Interaction With Symbiont Defense Response To Gram-negative Bacterium Negative Regulation Of Innate Immune Response Acute-phase Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Phagocytosis Negative Regulation Of Wound Healing
Tagcloud ?		2d apoa1 apoa4 biochemistry bioinformatic cfhr1 clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur