MASP2 and MBL2

Number of citations of the paper that reports this interaction (PubMedID 36100602)
67

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MASP2	MBL2
Description		MBL associated serine protease 2	mannose binding lectin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Symbiont Cell Surface	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body External Side Of Plasma Membrane Cell Surface Symbiont Cell Surface Serine-type Endopeptidase Complex
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding Calcium-dependent Protein Binding	Signaling Receptor Binding Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Zymogen Activation Killing Of Cells Of Another Organism Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Protein Maturation Killing By Host Of Symbiont Cells Antiviral Innate Immune Response Positive Regulation Of Opsonization
Pathways			Lectin pathway of complement activation Initial triggering of complement SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		beta-Hydroxyasparagine Narsoplimab	O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency	Tuberculosis Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Appendicular lean mass ( 33097823) Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)	Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 22504420 29499414) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)
Interacting Genes		4 interacting genes: C4A FCN2 MBL2 SERPING1	9 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2
Entrez ID		10747	4153
HPRD ID		05484	01107
Ensembl ID		ENSG00000009724	ENSG00000165471
Uniprot IDs		A0A8V8TPN9 A0A8V8TQY3 O00187	P11226
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 5JPM	1HUP
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Complement Activation Regulation Of Immune Response Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Positive Regulation Of Opsonization Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Opsonization Defense Response To Gram-positive Bacterium Serine-type Endopeptidase Complex Regulation Of Immune System Process Positive Regulation Of Endocytosis Innate Immune Response Cell Killing Defense Response To Symbiont Defense Response To Other Organism Humoral Immune Response Antigen Binding Positive Regulation Of Immune Effector Process Complement Activation, Classical Pathway Zymogen Activation Pattern Recognition Receptor Activity Defense Response To Bacterium Protein Maturation Positive Regulation Of Immune System Process Regulation Of Endocytosis Response To Other Organism External Side Of Plasma Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Immune Response Immune Effector Process Response To Bacterium Activation Of Immune Response Response To External Biotic Stimulus Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Defense Response Collagen Trimer Calcium-dependent Protein Binding Extracellular Space Defense Response To Gram-negative Bacterium Mannan Binding Regulation Of Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Immune Response Lipoteichoic Acid Immune Receptor Activity	Complement Activation, Lectin Pathway Complement Activation Complement Component C1q Complex Binding Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Activation Of Immune Response Spectrin Binding Carbohydrate Binding Positive Regulation Of Immune System Process Response To Other Organism Zymogen Activation Calcium Ion Binding Cell Surface Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Response To External Biotic Stimulus Positive Regulation Of Immune Response Humoral Immune Response Regulation Of Humoral Immune Response Plasma Membrane Raft Distribution Regulation Of Endocytosis Sarcoplasmic Reticulum Protein Maturation Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Location In Cell Maintenance Of Location Maintenance Of Protein Location In Plasma Membrane Amylin Receptor Complex 3 Calcitonin Receptor Activity Positive Regulation Of Phagocytosis Regulation Of Immune System Process Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Calcium-dependent Protein Binding Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Complement Component C4b Binding Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Calcium-mediated Signaling ERAD Pathway Immune Effector Process Secretory Granule Membrane Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Cell Communication By Electrical Coupling Cytoskeleton Organization Amylin Receptor 3 Signaling Pathway
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