MASP2 and SERPING1

Number of citations of the paper that reports this interaction (PubMedID 10946292)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		MASP2	SERPING1
Description		MBL associated serine protease 2	serpin family G member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Symbiont Cell Surface	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding Calcium-dependent Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation	Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis Blood Circulation Fibrinolysis
Pathways			Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade
Drugs		beta-Hydroxyasparagine Narsoplimab	PPL-100 Copper
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Appendicular lean mass ( 33097823) Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)	Autism spectrum disorder or schizophrenia ( 28540026) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		4 interacting genes: C4A FCN2 MBL2 SERPING1	17 interacting genes: BAG6 C1R C1S CFTR ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
Entrez ID		10747	710
HPRD ID		05484	06033
Ensembl ID		ENSG00000009724	ENSG00000149131
Uniprot IDs		A0A8V8TPN9 A0A8V8TQY3 O00187	E9KL26 P05155
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 5JPM	2OAY 5DU3 5DUQ 7AKV 8W18
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Complement Activation Regulation Of Immune Response Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Positive Regulation Of Opsonization Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Opsonization Defense Response To Gram-positive Bacterium Serine-type Endopeptidase Complex Regulation Of Immune System Process Positive Regulation Of Endocytosis Innate Immune Response Cell Killing Defense Response To Symbiont Defense Response To Other Organism Humoral Immune Response Antigen Binding Positive Regulation Of Immune Effector Process Complement Activation, Classical Pathway Zymogen Activation Pattern Recognition Receptor Activity Defense Response To Bacterium Protein Maturation Positive Regulation Of Immune System Process Regulation Of Endocytosis Response To Other Organism External Side Of Plasma Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Immune Response Immune Effector Process Response To Bacterium Activation Of Immune Response Response To External Biotic Stimulus Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Defense Response Collagen Trimer Calcium-dependent Protein Binding Extracellular Space Defense Response To Gram-negative Bacterium Mannan Binding Regulation Of Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Immune Response Lipoteichoic Acid Immune Receptor Activity	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Response To External Biotic Stimulus Zymogen Activation Activation Of Membrane Attack Complex Immune System Process Killing Of Cells Of Another Organism Opsonization Symbiont Cell Surface Peptidase Activity Extracellular Space Protein Processing Response To Other Organism Response To Stress Cell Killing Cell Surface Positive Regulation Of Leukocyte Tethering Or Rolling Defense Response Positive Regulation Of Immune System Process Negative Regulation Of Fibrinolysis Complement Activation Regulation Of Leukocyte Tethering Or Rolling Protein Maturation Proteolysis Regulation Of Fibrinolysis Fibrinolysis Immune Effector Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Immune Response Activation Of Immune Response Positive Regulation Of Blood Coagulation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Coagulation Defense Response To Symbiont Humoral Immune Response Defense Response To Other Organism Complement Activation, Classical Pathway Blood Microparticle Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Lipopolysaccharide Binding Trans-synaptic Signaling By BDNF Regulation Of Immune System Process Extracellular Region Biological Process Involved In Interaction With Symbiont Hydrolase Activity Complement Component C1 Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Cell Migration Negative Regulation Of Blood Coagulation
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