MASP2 and FCN2

Number of citations of the paper that reports this interaction (PubMedID 12421953)
0

Data Source:
HPRD (in vitro)

		MASP2	FCN2
Description		MBL associated serine protease 2	ficolin 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Symbiont Cell Surface	Extracellular Region Collagen Trimer Extracellular Space External Side Of Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle Symbiont Cell Surface Serine-type Endopeptidase Complex
	Molecular Function	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding Calcium-dependent Protein Binding	Antigen Binding Signaling Receptor Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Proteoglycan Binding Metal Ion Binding Calcium-dependent Protein Binding Lipoteichoic Acid Immune Receptor Activity Carbohydrate Derivative Binding Mannan Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Complement Activation Opsonization Zymogen Activation Killing Of Cells Of Another Organism Recognition Of Apoptotic Cell Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Maturation Positive Regulation Of Opsonization
Pathways			Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface
Drugs		beta-Hydroxyasparagine Narsoplimab
Diseases		Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Appendicular lean mass ( 33097823) Beard thickness ( 26926045) Body mass index ( 29273807) Eosinophil percentage of white cells ( 32888494) Male-pattern baldness ( 28196072)	Blood protein levels ( 30072576)
Interacting Genes		4 interacting genes: C4A FCN2 MBL2 SERPING1	2 interacting genes: MASP1 MASP2
Entrez ID		10747	2220
HPRD ID		05484	03376
Ensembl ID		ENSG00000009724	ENSG00000160339
Uniprot IDs		A0A8V8TPN9 A0A8V8TQY3 O00187	Q15485
PDB IDs		1Q3X 1SZB 1ZJK 3TVJ 5JPM	2J0G 2J0H 2J0Y 2J1G 2J2P 2J3F 2J3G 2J3O 2J3U 2J61 4NYT 4R9J 4R9T
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Complement Activation Regulation Of Immune Response Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Positive Regulation Of Opsonization Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Opsonization Defense Response To Gram-positive Bacterium Serine-type Endopeptidase Complex Regulation Of Immune System Process Positive Regulation Of Endocytosis Innate Immune Response Cell Killing Defense Response To Symbiont Defense Response To Other Organism Humoral Immune Response Antigen Binding Positive Regulation Of Immune Effector Process Complement Activation, Classical Pathway Zymogen Activation Pattern Recognition Receptor Activity Defense Response To Bacterium Protein Maturation Positive Regulation Of Immune System Process Regulation Of Endocytosis Response To Other Organism External Side Of Plasma Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Immune Response Immune Effector Process Response To Bacterium Activation Of Immune Response Response To External Biotic Stimulus Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Defense Response Collagen Trimer Calcium-dependent Protein Binding Extracellular Space Defense Response To Gram-negative Bacterium Mannan Binding Regulation Of Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Immune Response Lipoteichoic Acid Immune Receptor Activity	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Zymogen Activation Complement Activation Calcium-dependent Protein Binding Serine-type Peptidase Activity Killing Of Cells Of Another Organism Serine-type Endopeptidase Activity Protein Processing Cell Killing Humoral Immune Response Complement Component C4b Binding Protein Maturation Immune Effector Process Activation Of Immune Response Peptidase Activity Calcium Ion Binding Innate Immune Response Positive Regulation Of Immune Response Negative Regulation Of Complement Activation Complement Activation, Alternative Pathway Defense Response To Symbiont Defense Response To Other Organism Regulation Of Complement Activation Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Other Organism Complement Activation, Classical Pathway Immune Response Proteolysis Regulation Of Humoral Immune Response Response To External Biotic Stimulus Defense Response Extracellular Space Hydrolase Activity Regulation Of Immune System Process Identical Protein Binding Immune System Process Extracellular Region Negative Regulation Of Immune Response Protein Metabolic Process Response To Stress
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