TLE3 and HINFP

Number of citations of the paper that reports this interaction (PMID 17577209)
8

Data Source:
BioGRID (two hybrid)

		TLE3	HINFP
Gene Name		transducin-like enhancer of split 3	histone H4 transcription factor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cajal Body
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Enzyme Binding Histone Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Organ Morphogenesis Wnt Signaling Pathway	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Protein Localization Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		6 interactors: APP FOXG1 HINFP NDRG1 PIN1 SIX3	25 interactors: ATN1 CDYL2 EFTUD2 ELP4 GSPT1 JUND MBD2 MDC1 MIF4GD MKI67 MORF4L1 NIPBL NPDC1 POM121C PRRC2C RBM17 RBM26 RPUSD4 TLE3 TRA2B TRAF2 TRIM44 TTF2 U2AF1 ZNHIT1
Entrez ID		7090	25988
HPRD ID		02558	07387
Ensembl ID		ENSG00000140332
Uniprot IDs		H0YL70 Q04726	Q9BQA5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Neuroblast Migration Optic Vesicle Morphogenesis Synaptic Growth At Neuromuscular Junction Cell Maturation Brain Development Head Development Collateral Sprouting In Absence Of Injury Regulation Of Neural Retina Development Lens Fiber Cell Apoptotic Process Neuroblast Differentiation Negative Regulation Of Neuron Differentiation Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Proximal/distal Axis Specification Central Nervous System Development Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Multicellular Organismal Development Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Positive Regulation Of Cell Cycle Negative Regulation Of Neurogenesis Neuron Remodeling Forebrain Dorsal/ventral Pattern Formation Lens Induction In Camera-type Eye Positive Regulation Of Cell Cycle Checkpoint Negative Regulation Of Cell Development Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Developmental Process Telencephalon Regionalization RNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Circadian Behavior Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Rhythmic Behavior	RNA Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process RNA Processing RNA Splicing Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Histone Deacetylation Termination Of RNA Polymerase II Transcription Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Protein Deacetylation RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone H4 Acetylation Regulation Of RNA Metabolic Process ATP-dependent Chromatin Remodeling Pharynx Development DNA-templated Transcription, Termination Chromatin Modification Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair External Genitalia Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Maintenance Of Mitotic Sister Chromatid Cohesion Uterus Morphogenesis Gall Bladder Development Negative Regulation Of G0 To G1 Transition Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Positive Regulation Of Ossification Regulation Of RNA Biosynthetic Process Chromatin Organization Macromolecule Biosynthetic Process Histone Acetylation Cellular Response To X-ray MRNA Transport Internal Peptidyl-lysine Acetylation
Tagcloud ?		ablated adaptive adipocytes adipose concomitantly fed genetically glut4 hfd homeostatic improves irs knockout linchpin mature message mimicked peroxisome ppargamma preferentially proliferator qrt rosiglitazone s6k1 sc split subcutaneous t2d transducin	acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt5b wnt7b
Tagcloud (Difference) ?		ablated adaptive adipocytes adipose concomitantly fed genetically glut4 hfd homeostatic improves irs knockout linchpin mature message mimicked peroxisome ppargamma preferentially proliferator qrt rosiglitazone s6k1 sc split subcutaneous t2d transducin	acta2 amscs architectural cd105 cd73 cd90 chondrogenic confluence confluent cyto eng fibroblastic nes npat nt5e pou5f1 renewing rnaseq sfrp2 sfrp4 successively thy1 versatility wisp2 wnt2 wnt2b wnt5a wnt5b wnt7b
Tagcloud (Intersection) ?