TLE3 and FOXG1

Number of citations of the paper that reports this interaction (PMID 11238932)
27

Data Source:
HPRD (in vivo)

		TLE3	FOXG1
Gene Name		transducin-like enhancer of split 3	forkhead box G1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus
	Molecular Function	Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Organ Morphogenesis Wnt Signaling Pathway	Transcription, DNA-templated Brain Development Aging Negative Regulation Of Transcription, DNA-templated
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS		Height ( 20881960)	Longevity ( 20834067) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		6 interactors: APP FOXG1 HINFP NDRG1 PIN1 SIX3	16 interactors: APOE EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 TLE1 TLE3
Entrez ID		7090	2290
HPRD ID		02558	01283
Ensembl ID		ENSG00000140332	ENSG00000176165
Uniprot IDs		H0YL70 Q04726	P55316
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Neuroblast Migration Optic Vesicle Morphogenesis Synaptic Growth At Neuromuscular Junction Cell Maturation Brain Development Head Development Collateral Sprouting In Absence Of Injury Regulation Of Neural Retina Development Lens Fiber Cell Apoptotic Process Neuroblast Differentiation Negative Regulation Of Neuron Differentiation Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Proximal/distal Axis Specification Central Nervous System Development Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Multicellular Organismal Development Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Positive Regulation Of Cell Cycle Negative Regulation Of Neurogenesis Neuron Remodeling Forebrain Dorsal/ventral Pattern Formation Lens Induction In Camera-type Eye Positive Regulation Of Cell Cycle Checkpoint Negative Regulation Of Cell Development Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Developmental Process Telencephalon Regionalization RNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Circadian Behavior Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Rhythmic Behavior	Cellular Response To Growth Factor Stimulus Response To Growth Factor Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Cellular Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Macromolecule Biosynthetic Process Response To Transforming Growth Factor Beta Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Primary MiRNA Processing Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Differentiation Mesonephros Development Organ Development Mesoderm Development Anatomical Structure Development Cardiovascular System Development
Tagcloud ?		ablated adaptive adipocytes adipose concomitantly fed genetically glut4 hfd homeostatic improves irs knockout linchpin mature message mimicked peroxisome ppargamma preferentially proliferator qrt rosiglitazone s6k1 sc split subcutaneous t2d transducin	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?		ablated adaptive adipocytes adipose concomitantly fed genetically glut4 hfd homeostatic improves irs knockout linchpin mature message mimicked peroxisome ppargamma preferentially proliferator qrt rosiglitazone s6k1 sc split subcutaneous t2d transducin	accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Intersection) ?