TLE3

Gene Name		transducin-like enhancer of split 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Organ Morphogenesis Wnt Signaling Pathway
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-protein Interactions		6 interactors: APP FOXG1 HINFP NDRG1 PIN1 SIX3
Entrez ID		7090
HPRD ID		02558
Ensembl ID		ENSG00000140332
Uniprot IDs		H0YL70 Q04726
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Neuroblast Migration Optic Vesicle Morphogenesis Synaptic Growth At Neuromuscular Junction Cell Maturation Brain Development Head Development Collateral Sprouting In Absence Of Injury Regulation Of Neural Retina Development Lens Fiber Cell Apoptotic Process Neuroblast Differentiation Negative Regulation Of Neuron Differentiation Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Proximal/distal Axis Specification Central Nervous System Development Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Multicellular Organismal Development Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Positive Regulation Of Cell Cycle Negative Regulation Of Neurogenesis Neuron Remodeling Forebrain Dorsal/ventral Pattern Formation Lens Induction In Camera-type Eye Positive Regulation Of Cell Cycle Checkpoint Negative Regulation Of Cell Development Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Developmental Process Telencephalon Regionalization RNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Circadian Behavior Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Rhythmic Behavior
Tagcloud ?		ablated adaptive adipocytes adipose concomitantly fed genetically glut4 hfd homeostatic improves irs knockout linchpin mature message mimicked peroxisome ppargamma preferentially proliferator qrt rosiglitazone s6k1 sc split subcutaneous t2d transducin